Neuromodulators and Antidepressants

Question 1

What are selective serotonin reuptake inhibitors (SSRIs)

Answer 1

Lecture 20, slide 4-5

Question 2

What are the two paradoxes of serotonin’s effect on anxiety and depression?

Answer 2

Lecture 20, slide 6-10

Question 3

What was the early monoamine theory of depression? What evidence was it based on? What study contradicts this theory?

Answer 3

Lecture 20, slide 12-17

Question 4

What is the paradox of SSRIs use as anti-depressants?

Answer 4

Lecture 20, slide 18

Question 5

What is the Network (/Neural Plasticity) Hypothesis of depression and the function of antidepressant drugs? What is the hypothesis based on?

Answer 5

Lecture 20, slide 21-25

Question 6

What effects do anti-depressants have on the brain?

Answer 6

Lecture 20, slide 26-28

Question 7

Describe a study that shows SSRIs increase the plasticity of the adult brain in rats.

Answer 7

Lecture 20, slide 29-42

Question 8

What is adult neurogenesis? What evidence is there for it?

Answer 8

Lecture 20, slide 43-48

Question 9

In which brain regions does adult neurogenesis occur? What happens after adult neurogenesis?

Answer 9

Lecture 20, slide 49-50

-dentate gyrus (granule cell layer and SGZ)

Question 10

How do newborn cells exert an influence on the rest of the hippocampus? What study shows this?

Answer 10

Lecture 20, slide 51-56

Question 11

What is the Adult Neurogenic Theory of antidepressant drug function?

Answer 11

Lecture 20, slide 57-58

Question 12

Describe a study shows the effect SSRIs have on adult neurogenesis? How does the same study show that adult hippocampal neurogenesis is necessary for the behavioural effects of antidepressents?

Answer 12

Lecture 20, slide 59-78

Question 13

What is an issue with the Santarelli et al. study about the effect of antidepressants on behaviour and neurogenesis? How was this issue shown in a different study?

Answer 13

Lecture 20, slide 78-81