Sleep and Arousal Flashcards
Describe EEG characteristics of awake stage
- Low amplitude
- Random (desynchronized)
- High frequency
Describe EEG characteristics of drowsy stage
8-12 Hz alpha waves
Describe EEG of stage 1 sleep
3-7 Hz theta waves
Describe EEG of stage 2 sleep
- 12-14 Hz
- Sleep spindles (high freq)
- K-complexes (jolt response stage, high amplitude)
Describe EEG of Delta sleep
- High amplitude
- Slow (.5-2 Hz)
- Synchronous
Describe EEG of REM sleep
Mimics awake EEG
Which stage of sleep exhibits fast eye movements?
REM stage
What are the features of night’s sleep?
- Initially deeper sleep (go to stage 4) but as night goes on, go less and less deep
- REM states get longer in time and not as far apart as initially
What are features of the ascending reticular activating system (ARAS)
- Fell firing rates change with behavioral state
- Diffuse innervation of brain regions
- Projections between different brain regions
- Modulatory neurotransmitters (not glutamate)
Which nucleus does histamine come from?
(Tuberomammillary nucleus)
Which nucleus does noradrenaline come from?
Locus Coeruleus
Which nucleus does 5-HT come from?
Dorsal raphe
Which nucleus does Ach come from?
Basal forebrain, pedunculopontine tegmental nucleus (PPN)
Where does hypocretin/orexin come from?
Posterior lateral hypothalamus
What neurotransmitters promote WAKEFULNESS?
- Histamine
- Serotonin
- Norepinepherine
- Acetylcholine
- Hypocretin/Orexin