SLE Study Guide

Question 1

Drugs inducing SLE

Answer 1

Antiarrhythmic (Procainamide);
Anti-epileptic (Carbamazepine);
AntiHTN (Hydralazine; Methyldopa; Captopril); Antimicrobials (Quinidine; Isoniazid; Minocycline);
DMARD/Immunosuppressants (Sulfasalazine; TNF-a inhibitors; Interferons);
N/V (Chlorpromazine);
Thyroid (PTU)

Question 2

1st Line Tx for SLE

Answer 2

NSAIDs; Hydroxychloroquine (Plaquenil); Low dose glucocorticoids

Question 3

SLE tx preferred in pregnancy

Answer 3

Hydroxychloroquine (Plaquenil)

Question 4

2nd Line SLE tx or Tx for organ threatening dz

Answer 4

High dose glucocorticoids; Methotrexate; Cyclophosphamide; Azathioprine; Mycophenolate (Cellcept); Belimumab (Benlysta)

Question 5

Cyclophosphamide (Cytoxan) MoA

Answer 5

Alkylating agent preventing cell division by crosslinking DNA

Question 6

Cyclophosphamide (Cytoxan) Drawbacks

Answer 6

Route (IV); ADEs (Hemorrhagic cystitis; Bone marrow suppression); Monitoring (CBC, UA)

Question 7

Azathioprine (Imuran) MoA

Answer 7

Prevents DNA synthesis via inhibited purine metabolism

Question 8

Azathioprine (Imuran) Drawbacks

Answer 8

IV route; ADEs (Leukopenia, thrombocytopenia, ^LFTs); Monitoring (LFTs & CBC)

Question 9

Mycophenolate (CellCept) MoA

Answer 9

PO drug that inhibits antibody production

Question 10

Mycophenolate (CellCept) Drawbacks

Answer 10

Unlabeled use for SLE; ADEs (anemia, leukopenia, thrombocytopenia); Monitoring (CBC only)

Question 11

Belimumab (Benlysta) MoA

Answer 11

IgG 1-lambda prevents cell survival

Question 12

Belimumab (Benlysta) Drawbacks

Answer 12

Route (IV); Slow onset of action; ADEs (anaphylaxis, infusion rxn, bradycardia, depression); Monitoring (CBC only); NO LIVE VACCINATIONS WITHIN 30 DAYS