SLE

Question 1

95% of pxs. earliest abnormality

Answer 1

Arthralgia

Question 2

most common cause of death after 1st Five yrs

Answer 2

thromboses

Question 3

Predictor for Poor prognoses

Answer 3

Renal involvement

Question 4

Anti-body of relatively high specificity for active nephritis

Answer 4

Anti ds dna antibody and anti c1q antibody

Question 5

most frequent cardiac manifestation

Answer 5

Pericarditis

Question 6

A marker for patients at risk for CNS lesions

Answer 6

Livedo reticularis

Question 7

Drugs that cause drug iduced LE

Answer 7

Hydralazine 
procainamide 
sulfonamide 
penicillin 
anticonvulsant 
minocycline 
isoniazid 

DRUGS LE- PSH PAIM

Question 8

HLA DR 4 individuals who are slow acetylators are predisposed to develop what

Answer 8

Hydralazine induced LE

Question 9

age of onset of childhood SLE

Answer 9

bet 3-15 yo
girls more

oral mucosa freq involved.

Question 10

CYBB mutations have an What type of inheritance and carriers have a higher risK of DLE and SLE

Answer 10

X libked inheritance

Question 11

T suppressor cell function is inc or dec in px w LE ?

Answer 11

Decreased

Question 12

most frequent findings in urine

Answer 12

Albumin, rbc and casts

Question 13

AN a is positive and how many percent of SLE

Answer 13

95%

Question 14

Correlates with high-risk of renal disease

Answer 14

Ds DNA

Question 15

antibody common in SCLE And sjogren syndrome

Answer 15

ANti La antibodies

Question 16

found in 25% of SLE and 40% of sjogren syndrome

Answer 16

Anti Ro antibodies

Question 17

The safest agent for LE is what

Answer 17

anti malarials

Question 18

The single most effective local treatment for LE

Answer 18

Injection of steroid into lesion . triamcinolone acetonide 2.5-10mg/ml is injected at 4-6 wk interval. No more than 40 mg of triamcinolone.

Question 19

Drug particularly helpful in treating hypertrophic LE

Answer 19

Retinoids

Question 20

Thalidomide can be effective but is limited by the risk of

Answer 20

teratogenicitt and neuropathy.

TNT

Question 21

Drug of choice for bullous systemic LE

Answer 21

dapsone

Question 22

Systemic treatment reserved for acute flares of disease

Answer 22

oral Prednisone

Question 23

First line systemic therapy in most forms of cutaneous LE

Answer 23

Antimalarial- Hyrdoxychloroquine (plaquenil) 5mg/kg/day.

Question 24

Side effect for chloroquine this. it is used if there is no response after three months of treatment

Answer 24

ocular toxicity

Question 25

100 mg per day may be added to hydroxychloroquine because it adds no increased risk of retinal toxicity

Answer 25

Quinacrine

Question 26

Dose for corticosteroid systemic treatment

Answer 26

1000mg/day IV methypred for 3 days ff by oral prednisone 0.5-1mg/kg/day is effective in quickly reversing most clinical and serologic signs of activity of lupus nephritis