Lupus eruthematosus

Question 1

Manif of DLE/

Answer 1

In young adults and women.

dull red macules to plaques atrophy dcarring and oigment changes.

Question 2

Histo lupus:

Answer 2

epidermis demonstrate effacement of rete ridges pattern or irregular acanthoses. compract hyperkeratosis without parakeratosis. follicular plugginh.

Question 3

Elev cd3 and cd34 favor LP or DLE

Answer 3

LP

Question 4

a chronic unremitting form of Zle Affecting fingertiks, rims of ears, calves and heels spec women. usually oreceded by DLE on face.

Answer 4

Chilblain LE (Hutchinson)

Question 5

is a
Rear but distinctive entity. Patient present with edematous erythematous plaques usually on trunk.
histo: Patchy superficial depp perivascular and periasnexal lymphoid infiltrate that affects eccrine coil. Dermal mucin typical

Answer 5

Tumid Lupus erythematosus

Question 6

Tx for Tumid LE

Answer 6

Anti malaria

Question 7

LE panniculitis

Age gender

Answer 7

20-45

female

Question 8

LE panniculitis manif

Answer 8

decelop subc nodules firm sharply defined and non tender. proximal extremities are typically involved.
Histo: Lymphoid nodules in subcutaenous septa, necrosis of fat lobule, fibrinoid or hyaline degeneration of lipocytes. dermal mucin. dermal collagen hyalinization.

Question 9

SCLE gender age

Answer 9

White women

15-40

Question 10

SCLE MANIF

Answer 10

scaly and evolve as polycyclic annular lesuons or psoriasiform plaquesz vary from red tonpibk w faint violet tones. scale is thin and easily detached. tenglangiectasia and dyspigmentation.

occur usually on sun exposed areas.

Question 11

others

Answer 11

3/4 arthralgia or arthritis.
20% leukopenia
80% ANA test positive.

majority of cases have antibodies to Ro/SSA antigen.
+ for HLA DR3.
La/SSB may also be oresent and many pxs gave overlap feat w sjogren syndrome

Question 12

medication induced SCLE us traditionally most often related to what deug

Answer 12

Hydroxychlorothiazide

Question 13

SCLE positive w what HLA

Answer 13

HLA DR3
Ro/ssa
La/ssb may also be present

Question 14

SCLE histo

Answer 14

VID- K

Vacuoular interface dermatitis
Mild hyperkeratosis
parakeratosis

Question 15

manif if dec C4.

Answer 15

Hyperkeratosis palms and soles

Question 16

Neonatal lupus erythematosis are in girls born to mothers who carry what antibodyz

Answer 16

Ro/SSA antibody.

no skin lesions at birth. dev on 1st weeks of life.

Question 17

Neonatal lupus erythematosus manif

Answer 17

Annular erythematous macules and plaques mY appear on hand and extremities. periocilar involvement (racoon eyes) May be prominent.
resolv spont 6 months of age. health without scarring.

Question 18

Hao many months of close monitoring

Answer 18

first three months then by 9 mos of life most cases resolve w only 10% of infants w persistent antibodies at that time.

risk that second child will have neonatal LE- approx 25%

Question 19

sle

Answer 19

on book

Question 20

Localized DLE loc where

Answer 20

Discoud lesions usually above neck part on sun exposed siyes like scalp bridge of nose malar sreas lower lip and ears.

Question 21

hypertrophic LE lesions

Answer 21

Non pruritic papulonodular lesions on arms and handsresembling keratoacanthoma or hypertrophic LP.

dermoscopy dist scc and hypertrophic le

Question 22

lesions fround in LE not in LP

Answer 22

Bmz thickening
dermal mucin
eccrine coil involvement
subcutaneous nodular lymphoid infiltrates.

Question 23

LE - LP overlap syndrome

Answer 23

Lesions are large, atrophic, hypopigemnted red or pink plaques pigment abn become prominent over time and fine telangiectasias and scaling are usually present. extensor aspects of extremities and midline back are affected. 
prominent palmoplantar involvement. 
Nail dystrophy 
anonychia 
scarring alopecia and oral involvement. 

response to tx: poor.
top steroid dapsone thalidomide isotret- may be effective.
MMF

Question 24

histo lupus erythematosus panniculitis ( profundus)

Answer 24

lymphoid nodues in subcu septa

necrosis of fat lobule and fibrinoid or hyaline degeneration of remaining lipocytes.

Question 25

tx SCLE

Answer 25

sunprotection
antimalaria

medication induced scleA- Hydrochlorothiazide.

Question 26

c4 deficinecy leads to

Answer 26

hyperkeratosis ( palms and soles)