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HARRISON'S RHEUMA > SLE > Flashcards

SLE Flashcards

1
Q

Most common chronic dermatitis in lupus

A

Discoid lupus erythematosus

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2
Q

Most serious manifestation of SLE

A

Nephritis

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3
Q

Leading causes of mortality in the first decade of disease

A

Nephritis and infection

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4
Q

Most common manifestation of diffuse CNS lupus

A

Cognitive dysfunction

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5
Q

Primary manifestation of accelerated atherosclerosis in SLE

A

Myocardial infarctions

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6
Q 
Characteristics associated with increased risk for atherosclerosis in SLE, except
A. Female gender
B. Older age
C. Hypertension
D. High steroid dose
A

A.

Should be male gender

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7
Q

Most common pulmonary manifestation of SLE

A

Pleuritic with or without pleural effusion

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8
Q

Life threatening pulmonary manifestations
A. interstitial inflammation leading to fibrosis
B. shrinking lung syndrome
C. Intraalveolar hemorrhage
D. All of the above

A

D

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9
Q

Most frequent cardiac manifestation

A

Pericarditis

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10
Q

Most serious cardiac manifestation

A

Myocarditis

Fibrinous endocarditis of Libman-Sacks

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11
Q

Most frequent hematologic manifestation

A

Anemia, normochromic normocytic

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12
Q 
Serious ocular manifestations
A. Sicca syndrome
B. Nonspecific conjunctivitis 
C. Retinal vasculitis
D. Optic neuritis
A

C and D

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13
Q

ANA is positive in ___% of patients

A

> 95%

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14
Q

Autoantibodies specific for SLE

A

Anti-dsDNA

Anti-Sm

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15
Q

Note specific for SLE but identifies increased risk for venous or arterial clotting, thrombocytopenia and fetal loss

A

Antiphospholipid antibodies

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16
Q

Antiphospholid antibodies (3)

A

Anticardiolipin
Anti-B2-glycoprotein
Lupus anticoagulant

17
Q

Which of the following is true?
A. ELISA: anticardiolipin and anti-B2-glycoprotein
B. ELISA: anticardiolipin and lupus anticoagulant
C. Russell venom viper test: lupus anticoagulant and anticardiolipin
D. Russell venom viper test: lupus anticoagulant and anti-B2-glycoprotein

A

A.

ELISA: anticardiolipin and anti-B2-glycoprotein
Russell venom viper test: lupus anticoagulant

18
Q

Mainstay of treatment for any inflammatory life-threatening or organ-threatening manifestations of SLE

A

Systemic glucocorticoids

19
Q 
Most useful laboratory tests in Microvascular Thrombotic Crisis, except
A. ID of schistocytes on PBS
B. LDH elevation
C. Abs to ADAMS13
D. Creatinine elevation
A

D

20
Q

syndrome of positive ANA associated with symptoms such as fever, malaise, arthritis or intense arthralgias/myalgias, serositis, and/ or rash

A

Drug-induced lupus

21
Q

Autoantibody commonly associated with drug-induced lupus

A

Antibodies to histones

22
Q

Genetic signature in PB cells of 50-80%

A

Up regulation of genes induced by IFNs

23
Q

SLEDAI score likely to respond to Belimumab

A

10 or more

24
Q

SLEDAI score reflect clinically active disease

A

> 3

25
Q

SPF sunscreens

A

At least 15

Preferred 30

HARRISON'S RHEUMA (5 decks)

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