SLE Flashcards
Most common chronic dermatitis in lupus
Discoid lupus erythematosus
Most serious manifestation of SLE
Nephritis
Leading causes of mortality in the first decade of disease
Nephritis and infection
Most common manifestation of diffuse CNS lupus
Cognitive dysfunction
Primary manifestation of accelerated atherosclerosis in SLE
Myocardial infarctions
Characteristics associated with increased risk for atherosclerosis in SLE, except A. Female gender B. Older age C. Hypertension D. High steroid dose
A.
Should be male gender
Most common pulmonary manifestation of SLE
Pleuritic with or without pleural effusion
Life threatening pulmonary manifestations
A. interstitial inflammation leading to fibrosis
B. shrinking lung syndrome
C. Intraalveolar hemorrhage
D. All of the above
D
Most frequent cardiac manifestation
Pericarditis
Most serious cardiac manifestation
Myocarditis
Fibrinous endocarditis of Libman-Sacks
Most frequent hematologic manifestation
Anemia, normochromic normocytic
Serious ocular manifestations A. Sicca syndrome B. Nonspecific conjunctivitis C. Retinal vasculitis D. Optic neuritis
C and D
ANA is positive in ___% of patients
> 95%
Autoantibodies specific for SLE
Anti-dsDNA
Anti-Sm
Note specific for SLE but identifies increased risk for venous or arterial clotting, thrombocytopenia and fetal loss
Antiphospholipid antibodies
Antiphospholid antibodies (3)
Anticardiolipin
Anti-B2-glycoprotein
Lupus anticoagulant
Which of the following is true?
A. ELISA: anticardiolipin and anti-B2-glycoprotein
B. ELISA: anticardiolipin and lupus anticoagulant
C. Russell venom viper test: lupus anticoagulant and anticardiolipin
D. Russell venom viper test: lupus anticoagulant and anti-B2-glycoprotein
A.
ELISA: anticardiolipin and anti-B2-glycoprotein
Russell venom viper test: lupus anticoagulant
Mainstay of treatment for any inflammatory life-threatening or organ-threatening manifestations of SLE
Systemic glucocorticoids
Most useful laboratory tests in Microvascular Thrombotic Crisis, except A. ID of schistocytes on PBS B. LDH elevation C. Abs to ADAMS13 D. Creatinine elevation
D
syndrome of positive ANA associated with symptoms such as fever, malaise, arthritis or intense arthralgias/myalgias, serositis, and/ or rash
Drug-induced lupus
Autoantibody commonly associated with drug-induced lupus
Antibodies to histones
Genetic signature in PB cells of 50-80%
Up regulation of genes induced by IFNs
SLEDAI score likely to respond to Belimumab
10 or more
SLEDAI score reflect clinically active disease
> 3
SPF sunscreens
At least 15
Preferred 30
