SLE Flashcards
what is systemic lupus erythematosus (SLE)
multi system autoimmune disease
what gender is SLE more common in
females
age of onset SLE
20-40s
what HLA gene is associated with SLE
HLA DR3
what are the general non-specific symptoms of SLE
fatigue
weight loss
fever
myalgia
systemic features of SLE using A RASH POINts an MD pneumonic
Arthritis
Renal - lupus nephritis + Reynauds
ANA +ve (non specific) + Alopecia
Serositis - pleuritis + pericarditis
Haematological - anaemia, low WBC, low platelets
Photosensitivity
Oral ulcers
Immune - anti-ds DNA, anti-Sm
Neurological - seizures, psychosis
Malar rash
<strong>D</strong>iscoid rash
specific antibodies in SLE
anti-DsDNA
anti-Sm
what antibody is good for monitoring disease activity in SLE
anti-dsDNA
- Varies with disease actvitiy
presentation of arthritis in SLE
symmetrical polyarthritis
morning stiffness, no swelling
1st line treatment of SLE skin disease/arthralgia
hydroxychloroquine + short course steroids
treatment of organ threatening/resistent disease
cyclophosphamide + steroids
what drugs may be added if hydroxychloroquine insufficient
immunosuppression with methotrexate / azathioprine
what treatment is considered in unresponsive SLE
IV immunoglobulin / rituximab
why should urinalysis be regularly done in SLE patient
to check for protein / blood that may indicate glomerulonephritis
why should BP + cholesterol be regularly monitored in SLE patients
increased risk of cardiovascular disease (major cause of mortality)
- ischaemic heart disease
- hypertension
