SLE

Question 1

Antibodies of SLE

Answer 1

ANA positive …
Anti ds DNA, Anti Sm, ENA

Question 2

SLE - MD BRAIN SOAP

Answer 2

M- Malar rash
D- Discoid rash

B- Blood(all low: anaemia, leucopenia
thrombocytopenia)
R- Renal (proteinuria)
A- ANA positive
I - Immunological (ds-DNA, Anti Sm, ENA)
N- Neurologic (seizures)

S- Serositis (pleural, pericardial, joints)
O- Oral ulcers
A- Arthritis
P- Photosensitivity

> 4/11 SLE diagnosed

Question 3

Mild SLE features and RX

Answer 3

Only arthritis
Rx- NSAIDs

Question 4

Moderate SLE features and RX

Answer 4

Arthritis + Skin (mainly)
Rx - HCQ (antimalarial)

Question 5

Severe SLE features and RX

Answer 5

Multisystem involvement (heart, kidney etc), severe arthralgia
Rx -
Corticosteroids
Immunosuppressents (Azathioprine, Methotrexate, DMARDs-Rituximab, Belimumab)

Question 6

Arthritis is symm/asymm in SLE? Erosive/non-erosive?

Answer 6

Symmetrical (like RA)
Non-erosive (erosive in RA)

Question 7

Nameof non-infectious endocarditis
Sometimes present in SLE

Answer 7

Lidman Sacks endocarditis

Question 8

Which system involvement in SLE most commonly causes disability in pts

Answer 8

Renal (Lupus nephritis)

Question 9

Drugs causing SLE (QHIP)

Answer 9

Quinidine
Hydralazine
Isoniazid
Procainamide
DIL only presents as arthritis fatigue fever,
rarely pleurisy

Question 10

Are ANA and Anti histone antibodies present in drug induced lupus

Answer 10

Yes, even ANA are +
Except
1. Quinidine: ANA negative
2. Hydralazine: Anti histone Ab are positive only in 1/3 pts