Antibodies

Question 1

Antibodies tested for SLE

Answer 1

Most specific:
1. Anti ds-DNA
2. Anti Sm ( Smith)
3. ENA (Extractable nuclear antigens)

Others:
1. RF
2. ANA

First ANA done, if positive, check for specific antibodies

Question 2

Antibodies for Wegener granulomatosis

Answer 2

ANCA

Question 3

Antibodies for Sjogrens and SLE

Answer 3

Anti Ro (SSA)&raquo_space;
Anti la (SSB)

Question 4

RA factor can be positive in

Answer 4

1. Rheumatoid arthritis (high titres)
2. SLE
3. Systemic sclerosis
4. Sjogrens
5. Chronic liver disease
6. Viral hepatitis
7. TB
8. Malaria

Question 5

U1 RNP is an auto antibody for

Answer 5

Mixed connective tissue disorders
SLE

Question 6

Jo1 is an auto antibody for

Answer 6

Polymyositis

Question 7

CREST syndrome is positive for which antibody

Answer 7

Anti centromere

Question 8

Scleroderma is positive for which antibody

Answer 8

Anti topoisimerase
Anti centromere

Question 9

Anti phospholipid syndrome antibodies?

Answer 9

1. Anti phospholipid
2. Anti cardiolipin
3. Anti Beta GP1

Question 10

Anti histone Antibody is seen in

Answer 10

Drug induced lupus

Question 11

Types of ANCA and syndromes they are present in

Answer 11

c ANCA (Cytoplasmic): Wegeners granulomatosis
p ANCA (perinuclear): PAN, Churg strauss syndrome

Question 12

APA syndrome c/f

Answer 12

1. SLE +/-
2. Recurrent spontaneous abortions
3. DVT (arterial/venous thrombosis)
4. Thrombocytopenia
5. Skin ulcers
6. Livido reticularis

Aspirin 150-300mg daily
Refer

Question 13

APA in pregnancy, Rx

Answer 13

Recurrent abortions d/t placental infarcts
LMWH/Aspirin from 14wks to 6wks postpartum

Question 14

Which antibodies can transfer across placenta

Answer 14

Anti Ro/SSA (Sjogrens/SLE)
Causes neonatal lupus/heart block

Question 15

Are ANA and Anti histone antibodies present in drug induced lupus

Answer 15

Yes, even ANA are +
Except
1. Quinidine: ANA negative
2. Hydralazine: Anti histone Ab are positive only in 1/3 pts