SLE

Question 1

SLE etiology

Answer 1

1. genetic
2. hormones (estrogen)
3. environmental:
   - UV Exposure
   - Stress
   - Viruses
   - Chemicals or toxins
   - Medications (bacterium)

Question 2

Lupus types

Answer 2

Systemic Lupus Erythematousis

Cutaneous LE
only affects skin
characterised by butter fly rash

Drug induced L
certain meds that mimics signs and symptoms of sleep except theres no organ involvement.
caused by hydrolazine , procainamide and izomyacide. requires months and year of continuous use to develop.

Neonatal L
infant form of sleep
skin rash present at birth

Question 3

SLE risk factors

Answer 3

• UV Exposure (in the sun a lot)
• Stressed a lot
• Chemicals or toxins
• Medications (bacterium) so if you take that

Question 4

general pathophysiology

Answer 4

SLE is an autoimmune disease that attacks cells in tissues (type 3 hypersensitivity)

Question 5

4 common clinical manifestation of SLE then system signs

Answer 5

Fever
Weight loss
Joint Pain
Excessive Fatigue

systems:
Skin - butterfly rash , bald spots

Muscle - arthritis (swelling , pain stiffness, deformity, stabilization)

Hematologic - Anemia , Leukopenia (low wbc), thrombocytopenia (low platelets) , coagulation disorders

Lining of lungs
pleurisy - inflamamtion of tissue that lines the lungs
Heart
- pericarditis -
- myocarditis
- endocarditis
- fibrosis of sinoatrial & AV nodes
antiphosplipid syndrom (blod clots in bloos vessels)
raynauds - for perfusion , spasms that block blood flow
triggered by cold temp, anxiety or stress

CNS
- seizures
- headaches
- peripheral neuropathy
- cognitive problems ( disoriented and memory issues)
- depression
- anxiety

Kidneys (40-50% of ppl)
- mild proteinuria (leaking protein into urine, foamy urine)

• glomerulonephritis (inflammation of glomeruli, results in tubular damage and fibrosis, dec urine production , HEMATURIA, PROTEINURIA, EDEMA, WEIGHT GAIN, HIGH CREATINE (because the body is conserving fluid, puffiness in face)

Question 6

SLE diagnosis

Answer 6

Labs:
- Antinucelar antibody test (is a scare board. 10 or more score means she)

• anti-double stranded Dan test
• anti smith antibody
• anti phospholipid antibodies

x ray
ecg

Question 7

PHARM Treatment of SLE (CLASSES)

Answer 7

NSAIDS - reduce inflammation

Antimalarial - Dec antibody production

Corticosteroids -

honestly jus took at the chart

Question 8

Non-pharmacologic treatment

Answer 8

Nutrition
- no special diet
- no alcohol tho
- limit fat and salt intak
- limit calcium intake in presence of corticosteroids because those can worsen osteoporosis
- avoid alfalfa & garlic (can cause flaring)

Exercise
low impact, prevent damage to inflamed joint and muscles but maintain muscle and bone strength

Question 9

6 SLE complications

Answer 9

1. infections because of diffident antibody production to eliminate bacteria
2. end stage renal disease : renal issues cause scarring
3. stroke : antiphospholipid syndrome causes clots to form
4. heart attack
   from cv disease
5. preganancy complications:
   immune complexes are deposited in placenta and inflammation occurs, causes spontaneous abortion, still bitrth, or growth restriction in uterus
6. skin scarring
   discoloration caused by photosensitivity or rash from sun

Question 10

4 SLE Nursing management goals

Answer 10

Pain Management

Patient education
- make sure they’re aware and avoid activities that worsen their disease
what can trigger flares?

Maintain optimal role function
- wan individual to be independent

Positive self-image