Skin- Viral Flashcards
What is another name for measles
Rubeola
Measles epi
Winter/spring Young ages in developing countries Older ages in USA
What are the important proteins for measles
Hemagglutinin Fusion Matrix
Immunization of measles
Live attenuated vaccine best Given to infants 13-15 months Dont give live to immunocompromised or pregnant Second dose important for sustained immunity
HHV2 in babies
Spread via placenta 50% survival Survivors have permanent neuro impairment
Site of measles replications
Respiratory muscosal Skin Lymph Other organs
What puts you at risk for molluscum contagiosum
Shaving/bikini line wax
Rubella rash is seen when
1-2 days after onset of fever
Hand Foot and Mouth characteristics
Enterovirus Coxsackievirus A16 Causes fevers/blisters
Lab diagnosis of measles
Urine/Pharyngeal samples PCR Culture w/ monkey kidney cells Immuno- look for 4 fold rise in antibody titer
Parapoxvirus characteristics
Natural infection of sheep and goats At risk: sheepherders, vets
Measles is transmitted by what method
Respiratory spread Contagious 5 days before rash to 4 days after
Congenital rubella characteristics
Opacity in eyes
What kind of virus is varicellae
DNA
CMV can be seen in these patients
Leukemia Lymphoma AIDS
Describe skin of those with measles
Kopliks spots Maculopapular rash
What causes Roseola Infantum syndrome
Herpes 6B
Condylomata acuminata
Genital warts from Herpes
Rubella characteristics
Togavirus Enveloped Single stranded RNA One serotype Human reservoir
Roseola infantum syndrome sx
Abrupt onset High fever Brief convulsions
Treatment for Parvovirus B19
Transfusion
Tanapox characteristics
Africa Sometimes transmission to man Primate handler
Stages of chickenpox
Macular Papular Vesicular (early stage) Scab
Diagnosis of parapoxvirus
Look for cylinder and rounded ends wrapped with rope under microscope
What is the incubation period of measles
7-18 days
Late complications of congenital rubella
Diabetes Chronic thyroiditis Panencephalitits
Characteristics of Measles
Paramyxovirus RNA single stranded
Rubella lab diagnosis
PCR of respiratory secretions Screen for IgG and IgM, not IgM by itself
Rubella lab diagnosis of congenital
Titer comparison
Who is at risk for complications with chicken pox
Children with leukemia
Characteristics of Poxviridae
DNA Double stranded Replicates in cytoplasm Lipid envelope
Vaccine for chicken pox
Live virus- need to give before exposed to chicken pox
Herpes 6B characteristics
T cell lymphotropic virus 2 types 6B: Causes Roseola 6A: Adults- found in those with HIV
Clinical diagnosis of measles
Cough Ronny nose (coryza) Conjunctivitis
Herpes Labialis
fever blisters Recurrent
What carries monkey pox
Prarie dogs
Gingivostomatitis
Infection in children 1-5
What are the 3 syndromes of HHV-1
Gingivostomatitis Eczema Herpes Labialis Viral encephaslitis
How can you tell the difference between primary and secondary dengue
LEvels of IgM are smaller in secondary infection
Diagnosis of HHV1/2
PCR Direct stains (monoclonal fluorescent) Surgical path (Look for multinucleated giant cells… cowdry A intranuclear inclusions)
Is rubella congenital
Yes can be passed to unborn children- dangerous
Problems with Killed vaccines
Short lasting immunity Atypical measles syndrome
Clinical feature of HPV
warts Verruca plana- flat warts
Problems with live vaccines
Adverse reactions Can be inactivated by heat/time
Molluscum contagiosum characteristics
DS DNA Causes benign tumor of skin Warts take up color of skin (water wart) Pore in middle of papule
Congenital Parvo B19 can cause what
Hydrops fetalis
Monkey pox characteristics
Africa Zoonotics Can spread man to man but slower compared to small pox
Complications of measles
Encepthalitis Intersitial pneumonia Bacterial superinfections Subacute panencephalitis (worse- die years later)
Diagnosis for Zoster
ELISA PCR
