Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MD1 - Intersystems > Skin ST Infection > Flashcards

Skin ST Infection Flashcards

1
Q

What makes skin intrinsically resistant to infection?

A
  • Low pH
  • High salt
  • Low temperature
  • fats and fatty acids
  • microbiota
  • Low water content
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the common Bacterial causes?

A
  • Staph aureus
  • Str. pyo
  • Clostridium perfriengens
  • Pseudomonas
  • G-ves
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the common Fungal causes?

A
  • Candida
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Viral causes?

A

HSV, VZV, HPV, measles, rubella, enteroviruses, parovirus B19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the types of skin infections?

A
  • Localised: Folliculitis, abscess
  • Spreading: impetigo, celulitis
  • Necrotising: Fasciitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is a folliculitis?

A
  • Infection of hair follicle

- Staph aureus!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are some important Saph species?

A
  • Aureus = skin and systemic pathogen
  • Saprophyticus = UTI
  • Epidermidis = commensal; opportunist
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Staph aureus is coagulase what?

A

+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the pathogenesis of Staph aureus?

A
  • Adhere to damaged tissue via adhesins.
  • Inhibit chemotaxis via CHIPS
  • Inhibit phagocytosis via protein A, staphylokinase, SCIN, haemolysins
  • Can resist killing
  • BIofilm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is impetigo?

A
  • Epidermis infection
  • Bullous, crusted or pustular lesins
  • Staph aureus or Strep pyo! (often both)
  • Bullous caused by Staph aureus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is Erysipelas and cellulitis and whats the most common cause?

A
  • Erysipelas is a rapidly spreading superficial erythematous infection with defined borders + fever + pain
  • Cellulitis involves subcutaneous fat.
  • Caused by Strep pyo(GAS). Cellulitis can also be caused by S.aureus and Vibrio vulnificus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the cause of necrotising fasciitis and gangrene?

A
  • GAS including Clostridium species

- C.perfringens most common

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the GAS virulence determinants?

A
  • Adhesion and colonisation (M-Protein, lipoteichoic acid, fibronectin-binding proteins, others)
  • Evasion of innate immunity
  • DNAse
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the mechanisms of direct damage from GAS?

A
  • Direct: cytolethal toxins and enzymes
  • Superantigens
  • Activation of autoimmunity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are some sequelae of Strep pro infection?

A
  • Acute Rheumatic fever

- Post strem Glomerulonephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the 3 features of the Clostridia family

A
  • G+ve
  • Spore forming
  • Anaerobic
17
Q

Where is Clostridium perfringens normally found?

A

GIT

18
Q

What is the treatment for Impetigo (Staph aureus + Strep pyo)

A

Soap & water + mupirocin, or if more severe flucoxacillin or dicloxacillin

19
Q

What is the treatment for cellulitis? (Strep pyo)

A
  • Flucoxacilli
20
Q

Treatment for diabetic foot ulcer

A
  • Co-amoxoclav + metronidazole or dicloxacillin if GAS alone
21
Q

Treatment for Gas gangere

A

Pen G + Surgery

MD1 - Intersystems (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions