Skin soft tissue and plastics

Question 1

What are keratinocytes?

Answer 1

Main cell in the epidermis. Originate from the basal layer. Provides a mechanical barrier.

Question 2

What is the origin of melanocytes?

Answer 2

Neuroectodermal (neural crest cells) origin. Located in the basal layer. Have dendritic processes that transfer melanin to neighboring keratinocytes and malanosomes. Density of melanocytes is the same among races. Difference is amount of melanin produced.

Question 3

What is the role of Langerhans cells?

Answer 3

Langerhans cells (dendritic cells) – act as APC MHC class II. Originate from BM. Has a role in contact hypersensitivity type IV

Question 4

Sensory nerves:

Answer 4

• Pacinian corpuscles – deep pressure
• Ruffini’s endings – warmth, skin stretch
• Krause’s end bulb – cold
• Meissner’s corpuscles – light pressure, tactile sense

Question 5

What is the function of eccrine and apocrine sweat glands?

Answer 5

Eccrine:
Produce aqueous sweat for thermal regulation, usually hypotonic. Spread all over the body, with high concentration in palms and soles of feet.

Apocrine sweat gland - Milky sweat. Limited to the axilla, groin, anus.
- Hydradenitis is infection of apocrine sweat gland

Most sweat of above two is the result of sympathetic nervous system via ACH

Question 6

Treatment for hydradenitis

Answer 6

Treatment for mild  topical antibiotics or oral IV
Moderate to severe  TNF alpha inhibitor adalimumab
dapsone or cyclosporine provide variable results
Unroofing the sinus tracts  mild disease

Question 7

Pyoderma gangrenosum

Answer 7

• RF: antiperspirant, down syndrome, African Americans, obesity, female gender
• Tx: 1st hygiene (Avoid anti-perspirant) (avoid excessive sweating by avoiding hot climate) and abx.
• Surgical treatment provides best chance for cure  complete excision with split thickness skin graft
• Don’t excise with any active infection

Question 8

What is the predominant type of collagen in the skin?

Answer 8

Type I collagen, comprising 70% of the dermis, providing tensile strength.

Tension – resistance to stretch (collagen)
Elasticity - ability to regain shape (branching proteins can stretch 2x normal length)
Cushing’s striae - Decreased collagen results in loss of tensile strength and elasticity in dermis.
Stretch marks – damage to dermal collagen, blood vessel dilation and neovascularization occur

Question 9

What is the main complication of a pedicled or anastomosed free flap?

Answer 9

Free flap – detached from blood supply, inserted into another portion of body with microvascular anastomosis
Pedicled flap – uses original blood supply

MCC of pedicled or anastomosed free flap necrosis → venous thrombosis

Myocutaneous flap - blood supply to skin is from muscle perforators
Never do a flap with active infection

Question 10

What is a TRAM flap?

Answer 10

Tissue expansion occurs by local recruitment, thinning of the dermis and epidermis, mitosis
TRAM flap, transverse rectus abdominis musculocutaneous. = PEDICLED FLAP
- Is musculocutaneous flaps – takes skin, subq and underlying muscle
- Blood supply - superior epigastric vessels.
- Periumbilical mm perforators most important determinant of TRAM flap viability.
- Avoid left sided TRAM if previous CABG with left IMA use – compromises superior epigastric vessel
- Can’t use with previous transverse laparotomy that’s high (Chevron incision)
- Use contralateral rectus if chest XRT was used for breast CA (internal mammary artery compromised)
- Lap chole not a contraindication
- Highest risk for complications with smoking and obesity
- Complications – flap necrosis, ventral hernia, abdominal wall weakness

Question 11

What is a DIEP flap?

Answer 11

Deep inferior epigastric perforator flap, a free tissue transfer that takes fat and skin only.

Deep inferior epigastric perforator (DIEP) = FREE TISSUE TRANSFER
- Most commonly used for breast reconstruction
- Takes fat and skin only, no rectus muscle from lower abdomen = fasciocutaneous flap
- Anastomosis of inferior epigastric vessels to internal mammary artery and vein in the chest
- Major advantage  less complications from donor site
- Nerves and muscle not disturbed = less plain
- Shorter hospital stay
- Decreased risk of hernia at donor site
- Lower rate of fat necrosis
- Disadvantage Requires microsurgery  operation is much longer
- Can’t use on left if previous CABG with IMA use
- Replaced TRAM due to few complications with abdominal wal

Question 12

What is the first step in diagnosing a suspicious skin lesion?

Answer 12

Start with incisional biopsy (SCC and BCC) UNLESS concerned about melanoma, then you MUST do full thickness punch biopsy first and make sure to get down to SUBQ FAT

For most Soft tissue tumor start with Core needle biopsy
If that is non-diagnostic, then do incisional biopsy

Question 13

Basal cell carcinoma

Answer 13

MC cancer in the US
80% head and neck.
Malignancy of upper lip is almost always BCC
Rare on the lower lip

Rare nodal mets

Originates from epidermis – basal epithelial cells and hair follicles
Slow growth
Pearly, Waxy, with telangiectasias. Center ulceration with “rolled borders”
Morpheaform type - most aggressive has collagenase production
Peripheral palisading nuclei and stromal retraction on pathology
Rares mets or nodes
Regional adenectomy for rare clinically positive nodes
MC type is nodular
Tx: 4-5 mm margin. Unless high risk (morpheaform)  1 cm margin
- Do a lymphadenectomy only for clinically positive nodes
- Can do Moh’s surgery as first line treatment as well
If excision of SCC or BCC is not possible: radiation

Question 14

What is Moh’s surgery?

Answer 14

Moh’s Surgery – Confirms complete excision, takes as little tissue as possible
Indications: > 2 cm or cosmetically sensitive areas or positive margins after excision

Question 15

What is the recommended margin for excision?

Answer 15

4-6 mm margin down to subcutaneous fat.

Question 16

When is post-operative radiation needed?

Answer 16

For all with positive nodes, perineural invasion, and positive margins.

Question 17

What is the procedure for clinically positive nodes?

Answer 17

FNA/excisional biopsy; if positive, perform lymphadenectomy then radiation.

Question 18

What is the treatment for parotid basin lesions with clinically positive nodes?

Answer 18

Superficial parotidectomy and MRND.

Question 19

What is the treatment if excision of SCC or BCC is not possible?

Answer 19

Radiation.

Question 20

What margin is needed for Marjolin’s ulcer or penile/vulvar lesions?

Answer 20

For Marjolin’s ulcer or penile/vulvar = need 1-2 cm margin
Can treat high risk with Mohs surgery (minimizes area of resection) when resecting areas of face or highly sensitive areas

Question 21

What is the most common soft tissue sarcoma?

Answer 21

Undifferentiated pleomorphic sarcoma.

Question 22

What is the second most common soft tissue sarcoma?

Answer 22

Liposarcoma.

Question 23

Where are most soft tissue sarcomas located?

Answer 23

In the extremities (40%). Amputation is almost never the answer. Always limb sparing

Question 24

What is the prognosis for soft tissue sarcoma?

Answer 24

Very high local recurrence rate.

Question 25

What is the most common presentation of soft tissue sarcoma?

Answer 25

Sx: present with asymptomatic growing mass = MC presentation. GI bleed, bowel obstruction, neuro deficit

Question 26

What is the most common site for metastasis in soft tissue sarcoma?

Answer 26

Hematogenous spread!! Mets to nodes are rare Biopsy: Will show spindle cells, arise from mesenchymal tissue Lung MC site for mets

Question 27

What is the most important prognostic factor for soft tissue sarcoma?

Answer 27

Staging is based on tumor grade (undifferentiated is worse) Most important to improve survival  R0 surgical resection Tumor grade is the most important prognostic factor. Other prognostic factors, tumor size, pathologic stage

Question 28

What are the risk factors for soft tissue sarcoma?

Answer 28

Asbestos (mesothelioma), PVC, arsenic, vinyl chloride, thorotrast -> angiosarcoma, chronic lymphedema (lymphangiosarcoma), previous radiation.

Question 29

Soft tissue sarcoma dx/ staging

Answer 29

- Need the below imaging BEFORE any biopsy – need it to rule out vascular, nerve or bone invasion - All extremity/trunk/head/neck sarcomas need an MRI - All retroperitoneal lesions need abdominal CT  These also need core needle biopsy - After imaging  CORE NEEDLE BIOPSY always first choice, if unable to get or fails then below: - Longitudinal incisional biopsy - Need to eventually resect biopsy skin site if + for sarcoma - Biopsy along the long axis plane of future incision for resection - Don’t raise flaps, or disturb tissue planes. Do not enucleate. Just do incisional biopsy leaving bulk behind - !!!For visceral or retroperitoneal sarcoma – Imaging can be diagnostic, if it’s not then will need CNBx Staging: - Chest CT to rule out lung mets

Question 30

Soft tissue sarcoma tx

Answer 30

Tx: - Radical EN-BLOC resection with grossly negative, 1 cm margins and include the fascia. No frozen section. - Myxofibrosarcoma and dermatofibrosarcoma protuberans  need 2 cm margins - Need to include incision/core needle biopsy scars in resection - If nerves, vessels are near resection, they should be keletonized - >5 cm or high-grade  Neoadjuvant radiation, especially if you want to downsize tumor - >5 cm or high-grade positive margins, recurrence if didn’t give neoadjuvant radiation, need adjuvant here - Neoadjuvant chemo for high grade tumors > 10 cm - < 5 cm, > 1 cm margin, low grade  Do not need radiation - If you have positive margin go back to OR for resection, PLUS give radiation!! - Local recurrence  resect only if you can get R0 resection - Chemo and XRT have not changed survival, only decrease local recurrence - Chemo has very limited role in sarcoma of extremities - Always attempt limb salvage, try to avoid amputation - If sarcoma massively involves nerves, vessels, bone and would require amputation  Do neoadjuvant radiation - Isolated mets should be resected!! Pulmonary metastectomy improves overall survival - Only need wedge resection - Midline incision for pelvic or retroperitoneal sarcomas - Try to preserve motor nerves, and renal vessels

Question 31

Poor prognosis for retroperitoneal sarcoma overall due to

Answer 31

- Delay in diagnosis - Difficulty with resection - Difficulty getting XRT to pelvic and retroperitoneal tumors - 40% 5-year survival rate with complete resection

Question 32

Post mastectomy reconstruction

Answer 32

Post mastectomy reconstruction are either flap based or implant based: - Flap based – Must be delayed until after radiation. Much larger surgery - Implant based – uses tissue expanders 1st, THEN place implant after radiation. Generally, require 2 surgeries.

Question 33

Pressure sores:

Answer 33

Pressure sores: - Stage I - non-blanchable erythema, skin intact. Tx: keep pressure off - Stage II – Partial, epidermis is lost, and into dermis. Tx: Local treatment, keep pressure off - Stage III – Full thickness. Through the dermis. SubQ fat exposure tx: sharp debridement. Likely need myocutaneous flap - Stage IV – Involves fat, bone, muscle or tendon exposed. Tx: Myocutaneous flap - Unstageable – If you cannot see the depth due to eschar or slough

Question 34

UV radiation

Answer 34

UV radiation Damages DNA and repair mechanisms RF for SCC, basal cell, and melanoma Melanin single best factor for protecting skin from UV radiation. Absorbs radiation and dissipates as heat UV-A- Causes skin aging/wrinkling. Also has some part in CA. Responsible for tanning UV-B causes SKIN DAMAGE, sunburn, and has greatest damage to DNA and role in causing cancer

Question 35

Melanoma Risk Factors:

Answer 35

- Genetic risk factors are the highest risk!! - Familial BK mole syndrome – 100% risk of melanoma - Having > 50 moles on body - Fair complexion - Sun exposure, mostly UVB that causes CA, some with UVA found in tanning beds - Xeroderma pigmentosum - XRT - 10% of melanomas familial

Question 36

Familial atypical multiple mole and melanoma

Answer 36

Many moles on body - Risk of melanoma and pancreatic cancer - P16, CKD4

Question 37

Melanoma

Answer 37

MC in back for men, legs for women Worse prognosis for high mitotic rate, increased thickness, men, ulcerated, ocular, mucosal, increased # of nodes, location on back, posterior arms/neck/scalp Blue color  most ominous sign Originates from neural crest cells (melanocytes) in the basal layer of epidermis MC site for mets is lung MC mets to small bowel is melanoma Check tumor for BRAF mutation  can target with immunotherapy Dabrafenib Targets BRAF, indicated for treatment of unresectable or metastatic melanoma that harbors BRAF Check for PD-1 mutation  Targeted with Pembrolizumab Stains for S-100 and HMB-45 protein Dx: - Always start with punch biopsy, and make sure to get down to SUBQ FAT – biopsy the most suspicious (Most pigmented, most irregular, most raised) area - Face, hands feet - always want punch biopsy - Can get excisional biopsy with 1 mm margin for lesions < 2 cm – NOT in cosmetically sensitive area Thin melanoma = < 1 mm depth Intermediate melanoma = 1-4 mm Thick melanoma = > 4 mm Staging: CT ch/abd/pelvis, LFT, LDH for all melanoma > 1 mm. Examine all draining LN Tx: Resection, go down to muscle/fascia. - In situ = 0.5 cm margin - ≤1 mm = 1 cm margin - ≥1.1- 2.0 mm = 1 - 2 cm margins - > 2.0 mm = 2 cm margins Isolated SINGLE mets to lung, liver, EVEN BRAIN should be resected - This is best chance for cure. Provided patients with long term survival For disseminated metastasis  immunotherapy IL-2 and tumor vaccines used for node or metastasis

Question 38

Melanoma Types

Answer 38

Types: - Melanoma in situ or thin lentigo maligna (Hutchinson’s Freckle) - just the epidermis. Can do 0.5 cm margins - Lentigo maligna melanoma - least aggressive. Radial growth 1st. Presents as elevated nodule. - Superficial spreading - MC type. Intermediate malignancy, originates from nevus or sun exposed area - Acral lentiginous - very aggressive. Palm/soles of African Americans. Subungual (fingernail) - Nodular - Most aggressive. Most of them have metastasized at the time of dx. Vertical growth. Bluish black with smooth borders. Occurs anywhere on the body

Question 39

Melanoma Nodes:

Answer 39

Nodes: - Four nodal basins: inguinal, axillary, parotid, and cervical - Melanoma that require SLNBx: - All > 0.8 mm depth - If < 0.8 mm and has any below: - Ulcerated lesion - High mitotic rate - If SLNBx positive you have two option - US surveillance Q4 months (preferred) - Completion lymphadenectomy - Clinically positive nodes do FNA 1st, if inconclusive  excisional biopsy. If positive = formal resection - You are trying to clear the tumor, not stage (like breast CA). - Parotid basin: scalp/face melanoma anterior to ear and above upper lip, including earALL need superficial parotidectomy AND SLNBx (20% mets to parotid) - If superficial parotid gland is positive for CA  total parotidectomy and MRND - If SLNBx is positive  need MRND vs US - If clinically positive nodes superficial parotidectomy and MRND - Axillary node melanoma (or any other nodal basin) and no primary tumor found→ complete axillary dissection I, II, and III (unlike breast CA) primary tumor may have regressed or is unpigmented - May need to divide pectoralis minor to get to level III nodes - Superficial inguinal lymph node dissection- first biopsy node of Cloquet, if positive, also need deep nodes. - Boundaries of dissection in femoral triangle - inguinal ligament superiorly, adductor magnus medially, sartorius Line of Sappey – 2 cm above umbilicus at L2/L3 - Above line  melanoma goes to axillary nodes - Below line  melanoma goes to inguinal nodes

Question 40

Subungal melanoma

Answer 40

If melanoma in situ  wide length excision Remove nail and get a punch biopsy Thumb – amputate DIP Finger – amputate PIP Great Toe – Amputate at mid proximal phalanx. Never do a ray amputation of great toe if you can avoid it. Need it for balance Rest of toes – amputate mid proximal phalanx

Question 41

SCC of skin

Answer 41

Overlying erythema. Papulonodular with crust. Scaly plaques. Ulceration with pink borders. Red-brown. Satellite nodules Mets more common than BCC Skin malignancy of lower lip is almost always SCC MC skin cancer in transplant patients. Considered HIGH risk in them b/c immunosuppressed Can develop after XRT or old burn scars Actinic keratosis – precursor to SCC. Described as a sand paper like rash. Tx: topical 5FU 1st line or Imiquimod. Can do surgery  cauterize the lesions Keratoaconthoma = Central keratin filled plug. Risk of Cancer  Tx: Excision RF = HPV, sun exposure, xeroderma pigmentosum, Bowen’s disease, atrophic epidermis, previous XRT RF for mets: poorly differentiated, greater depth, recurrent lesions, immunosuppression Tx: 4-6 mm margin down to subcutaneous fat. Can do Moh’s - Post-op radiation needed for all with positive nodes, perineural invasion, and positive margins - Clinically positive nodes  FNA/excisional biopsy if positive  lymphadenectomy then radiation Parotid basin lesion with clinically positive nodes  superficial parotidectomy and MRND If excision of SCC or BCC is not possible  radiation

Question 42

Head and neck sarcoma

Answer 42

Usually in pediatric, usually get rhabdomyosarcoma Difficult to get margins due to proximity of vital structures Post op XRT for close margins (you basically can never get a full resection here)

Question 43

Retroperitoneal sarcoma

Answer 43

CT abd/pelv = sufficient for diagnosis. Imaging can be diagnostic, however always get core needle biopsy when possible. MC is liposarcoma. Also, leiomyosarcoma is common Especially poor prognosis due to delayed diagnosis and incomplete resection. Also, trouble with XRT due to proximity of vital structures Ability to completely remove the tumor (take kidney, colon, liver if need be) is the most important prognostic factor Debulking of primary or recurrent tumors is NOT recommended. Fails to improve overall survival. Only operate if you can get all the tumor or if there is an obstruction you need to relieve. !!!!Adjuvant radiation or chemotherapy is not standard of practice for retroperitoneal liposcarcomas!!!!! Need to rule out lymphoma  MC retroperitoneal tumor overall

Question 44

Kaposi’s Sarcoma

Answer 44

Vascular sarcoma Oral and pharyngeal mucosa are the MC sites. Bleeding, dysphagia Rarely a cause of death for AIDS  slow growing Tx: Primary goal is palliation - AIDS Tx shrinks AIDS related KS  best tx - Surgery for severe intestinal hemorrhage

Question 45

Childhood rhabdomyosarcoma

Answer 45

#1 soft tissue sarcoma in kids Head/neck MC site in children Embryonal subtype – MC Alveolar subtype – worst prognosis Rhabdomyosarcoma contains desmin Botryoides  vaginal rhabdomyosarcoma Tx: Surgery; doxorubicin based chemo

Question 46

Bone sarcoma

Answer 46

Most are metastatic at the time of diagnosis Osteosarcoma - increased incidence around knee. Originates from metaphyseal cells. Usually in children - Mets to lung should be resected if can get all of it, and primary tumor resected

Question 47

Li-Fraumeni syndrome

Answer 47

– Autosomal Dominant familial cancer with p53 tumor suppressor mutation. - Diagnosis requires: - Patient has a diagnosis of soft tissue Sarcoma (childhood rhabdomyosarcoma) CA before 45 - Have a 1st relative diagnosed with any cancer before 45 - Have another 1st or second degree relative diagnosed with sarcoma at any age or any other CA before 45 - Most common two cancers: rhabdomyosarcoma and breast cancer 70% risk

Question 48

Retinoblastoma

Answer 48

RB, also includes sarcomas, melanoma

Question 49

VHL

Answer 49

VHL – RCC, hemangioblastoma of retina and CNS, pheochromocytoma

Question 50

Tuberous sclerosis

Answer 50

Tuberous sclerosis - Angiomyolipoma

Question 51

Gardner’s syndrome

Answer 51

Gardner’s syndrome – FAP and intra-abdominal desmoid tumors

Question 52

Dermatofibrosarcoma protuberans

Answer 52

Dermatofibrosarcoma protuberans – soft tissue tumor Excellent survival rate, rarely metastasizes. However, they recur locally, often Flesh colored plaques on skin. CD34 positive. Tumor from fibroblasts. Pathology shows finger like projections of spindle cells - Tx: wide local excision with 2 cm margins - Imatinib for locally advanced or metastatic tumor

Question 53

Neurofibromatosis, AD:

Answer 53

- Neurofibromatosis I (von Recklinghausen) –peripheral sheathe tumors (neurofibroma, neurolemma), pheochromocytoma. - NF type II – Only get acoustic neuromas - AD - café-au-lait spots, axillary freckling

Question 54

Acanthosis nigricans

Answer 54

paraneoplastic dermatosis Usually affects and intertriginous areas (axilla, groin, knees and elbows) Velvety thickened hyperkeratotic plaques Associated with DM and insulin resistance New onset in older patients, associated with malignancy MC gastric, also lung CA When found on palms  concern for CA

Question 55

Xanthoma

Answer 55

Xanthoma - cholesterol rich, yellow, contains histiocytes. Benign

Question 56

Neuroma

Answer 56

Neuroma – associated with NF/von Recklinghausen’s, peripheral and CNS tumor

Question 57

Keratosis

Answer 57

- Actinic keratosis - Premalignant to SCC of skin. Sun damaged area. Need excisional biopsy if suspicious. Tx: topical 5FU - Seborrheic keratosis – NOT premalignant. Trunk on elderly. Dark. - Arsenical keratosis - associated with SCC

Question 58

Keratoacanthoma

Answer 58

- rolled edges, crater filled with keratin - Risk of squamous cell CA - Always bx these - Tx: excision

Question 59

Merkel cell carcinoma of skin

Answer 59

Neuroendocrine Very aggressive, Spreads to nodes Expands rapidly Pink then progresses to purple or blue to violaceous nodules or plaques “blue skin lesions” MC mets to bone Merkel cell polyomavirus genome found in tissue samples Cytokeratine-20 positive. CK20 Have neuron specific enolase NSE, neurofilament protein Keratin bodies show perinuclear pattern Initial work up: US of lymph node basins and total body scanning Tx: - Wide local excision, sentinel LNBx and post op radiation need 1-2 cm margin

Question 60

Glomus tumor

Answer 60

Painful, composed of blood vessels and nerves Benign. MC in the terminal aspect of digit Tx: tumor excision

Question 61

Paraganglioma

Answer 61

Rarely malignant, neural crest cells Part of autonomic nervous system From Glomus cells MC location: abdomen. MC ENT location: carotid body Can secrete norepi, highly vascular Tx: excision

Question 62

Felon

Answer 62

Abscess in the fingertip, does not involve nail bed Tx: Must DO incision and drainage in midline of digital pulp. Avoid lateral incisions (injures nerves)

Question 63

Paronychia

Answer 63

Abscess at edge of fingernail Tx: Warm compress, unless systemic effects then Incision at the lateral nail fold

Question 64

Retroperitoneal fibrosis

Answer 64

-Periaortic, surrounds ureters and causes obstruction of ureter, and acute renal failure - MC idiopathic, other causes is methysergide, XRT - Elevated ESR - Medial deviation of ureters is classic on CT - Malignant tumors can cause retroperitoneal fibrosis, so you if there is suspicion for CA rule out with CT guided biopsy - Treatment: o Give all patients steroids 1st line o Relieve obstruction (stents or nephrostomy tube) - Mainstay of treatment is steroids for  mild hydronephrosis without renal compromise - If renal function compromised or moderate to severe hydronephrosis  1st line: Place ureteral stents o 2nd line: Nephrostomy tubes - Surgery reserved for refractory to medical management with ureterolysis and wrap ureter with omentum

Question 65

Epidermal inclusion cyst

Answer 65

- Epidermal inclusion cyst (sebaceous cyst, epidermoid cyst) - Most common. Have completely mature epidermis with creamy keratin material

Question 66

Trichilemmal cyst

Answer 66

- Trichilemmal cyst – In scalp. No epidermis. Contain keratin from hair follicles

Question 67

Ganglion cyst

Answer 67

- Ganglion cyst – Found over joints. Usually wrist. Filled with synovial fluid. Tx: Treatment is surgical excision of symptomatic. Leave alone otherwise. Aspiration has high recurrence risk. Need to remove the check valve with surgery.

Question 68

Dermoid cyst

Answer 68

- Dermoid cyst – Midline intra-abdominal and sacral lesions usual. Needs resection due to risk of malignancy

Question 69

Pilonidal cyst

Answer 69

Use elliptical incision to encompass all the skin and SubQ, Go down to presacral fascia Make incision off of midline to decrease tension if needed Most conservative management is unroofing the pilonidal sinus tract

Question 70

Keloid

Answer 70

Keloid – Genetic!! Autosomal dominant More common In African American Contains disorganized Type I and type III collagen Occurs due to failure of collagen breakdown Excision has 100% recurrence rate Tx: 1st silicone pressure dressings, if that fails then intralesional steroids

Question 71

Hypertrophic scarring

Answer 71

Not genetic Contains well-organized type III collagen Occurs due to hypervascularization Tx: 1st silicone pressure dressings, if that fails then intralesional steroids

Question 72

Order of healing of skin grafts

Answer 72

Question 73

Melana lower extremity, palpable lymphadenopathy

Answer 73

-Dissection of superficial inguinal lymph node basin -6 to 10 cm incision extending from 2-4 cm below inguinal ligament -Saphenous vein at junction of sartorius and adductor muscles: preserved -Lateral cutaneous femoral nerve running under fascia of sartorius (preserved) -Femoral nerve, artery, vein within femoral triangle: preserved -Cloquet's node within femoral canal: excise and close defect in lacunar ligament -Mesh or sartorius flap can be used to cover residual defects