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Absite > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

MCC of CA death in women and men
MC CA in women
MC CA in men

A

MCC of CA death in women and men = lung
MC CA in women = breast
MC CA in men = prostate

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2
Q

Cisplatin

A

Ototoxic, nephrotoxic

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3
Q

Carboplatin

A

B myeloid suppression

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4
Q

Cyclophosphamide

A

Acrolein is the active metabolite. Mesna can help with hemorrhagic cystitis

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5
Q

Methotrexate

A

– inhibits dihydrofolate reductase  inhibits purine synthesis. Renal toxicity. Leucovorin rescue reverses effects of MTX

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6
Q

5FU

A

– SE: Myeloid suppression. inhibits thymidylate synthetase  inhibits purine synthesis. Leucovorin increases 5FU toxicity

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7
Q

Leucovorin

A

Leucovorin = folinic acid

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8
Q

Oxaliplatin

A

Oxaliplatin – SE Nephrotoxic, neurotoxic, ototoxic, (less than cisplatin)

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9
Q

Gemcitabine

A

Inhibits thymidylate synthetase

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10
Q

Vincristine

A

Vincristine – inhibits microtubule synthesis – peripheral neuropathy

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11
Q

Etopisode

A

S/E: Bone marrow suppression

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12
Q

Taxanes

A

Taxanes – Promote microtubule formation! S/E: cause neuropathy

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13
Q

Bevacizumab (Avastin)

A

Bevacizumab (Avastin) – VEGF inhibitor. Used in lung CA and metastatic colorectal CA

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14
Q

Esophageal CA

A

Esophageal CA – Carboplatin and paclitaxel

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15
Q

ENT chemo

A

ENT chemo – Cisplatin and 5FU

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16
Q

Squamous cell CA in Anal margin lesions (below the dentate line)

A

Squamous cell CA in Anal margin lesions (below the dentate line) – Cisplatin and 5FU

17
Q

Colorectal adenocarcinoma

A
  • First line = 5FU, leucovorin, and irinotecan (FOLFIRI). Add Bevacizumab (Avastin) if metastatic cancer
  • 2nd line: 5FU, leucovorin, oxaliplatin (FOLFOX).

For metastatic cancer 
- Cetuximab only if EGFR positive and metastatic
- Bevacizumab if metastatic (VEGF inhibitor)

18
Q

Anal canal (above dentate line) squamous cell CA

A

5FU and mitomycin with XRT (Nigro protocol)

19
Q

Small cell lung CA

A

Small cell lung CA – cisplatin and etoposide (VP16)

20
Q

Non-seminoma and Seminoma (germ cell tumors)

A

Non-seminoma and Seminoma (germ cell tumors) – cisplatin, bleomycin, etoposide

21
Q

Bladder CA

A

Bladder CA –MVAC; Methotrexate, vinblastine, Adriamycin, cisplatin

22
Q

Gallbladder

A

Gallbladder – Gemcitabine + cisplatin or Gemcitabine + capecitabine

Cholangiocarcinoma – Gemcitabine + cisplatin

23
Q

Pancreatic CA

A

FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) or gemcitabine

24
Q

GIST

A

Imatinib

25
Q

Carcinoid (used for unresectable disease)

A

Carcinoid (used for unresectable disease) – streptozocin and 5FU, octreotide

26
Q

Insulinoma

A

5FU and streptozocin, diazoxide

27
Q

Ovarian CA
Cervical CA

A

Cisplatin and paclitaxel

28
Q

Breast CA

A

TAC  Taxanes (docetaxel pacletaxal), doxurubicin, and cyclophosphamide

29
Q

Nephroblastoma (Wilm’s) – Actinomycin and vincristine

A
30
Q

Neuroblastoma - (DECC) doxorubicin, etoposide, cisplatin and cyclophosphamide

A
31
Q

Non-small cell lung CA (squamous or adenocarcinoma) - carboplatin, taxol (paclitaxel)

A
32
Q

Hodgkin’s - (ABVD – Adriamycin, bleomycin, vinblastine, dacarbazine)

A
33
Q

Radiation therapy XRT

A

M phase (mitosis) – most vulnerable stage of cell cycle for XRT. Targets this
Damage done by formation of oxygen radicals  maximal effect with high oxygen level
Main target is DNA – XRT and oxygen radicals damage DNA
Higher energy radiation has skin preserving effect (Maximal ionizing potential not reached until deeper structures)
Fractionate XRT doses allows:
- Repair of normal cells
- Re-oxygenation of tumor
- Redistribution of tumor cells in cell cycle
Very radiosensitive tumors (high mitotic rate) – Seminoma, lymphoma
Very radioresistant – epithelial, sarcoma

34
Q

Antibodies

A

Absite (39 decks)

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