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MSK 2 > Skin Path CIS > Flashcards

Skin Path CIS Flashcards

1
Q

Biopsy of 3 of 100 tan to brown macules (2mm-8mm) all over the body in non/sun exposed areas. Biopsy show single and clustered atypical melanocytes at the DE junction w/o upward migration, linear fibrosis of the superficial dermis, and sparse inflammatory infiltrate in dermis.

A

dysplastic nevus syndrome

*melanocytes

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2
Q

increased pigment in basal keratinocytes

A

ephelis

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3
Q

Tumor on legs of middle-age and young women. Asx or tender. indolent behavior. Hx of antecedent trauma. Factor 13a-positive dermal dendritic cells.

A

B9 Fibrous Histiocytoma (dermatofibroma)

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4
Q

Firm, tan to brown papules. B9, spindle shaped cells. Many cases demonstrate a peculiar form of overlying epidermal hyperplasia, characterized by downward transformation….

A

B9 Fibrous Histiocytoma (dermatofibroma)

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5
Q

may suddenly appear in large numbers as part of a paraneoplastic syndrome (leser trelate sign) due to stimulation of keratinocytes by transforming GF-alpha produced by tumor cells of the GI tract. FGFR3

A

seborrheic keratoses

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6
Q

Flat, coin like, waxy plaques

A

seborrheic keratoses

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7
Q

scaly, red brown patches

A

Mycosis Fungoides (CTCL)

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8
Q

CDNK2A gene LoF (skin)

A

dysplastic nevi

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9
Q

“peculiar linear fibrosis” (skin)

A

dysplastic nevi

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10
Q

BRAF (skin)

prognosis?

A

sporadic melanoma

better - have monoclonal antibody to BRAF

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11
Q

FGFR2 (skin)

A

SK’s and acanthosis nigricans (PCOS), achondropalsia

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12
Q

MSH2, MLH1 (skin)

A

HNPCC and Muir Torre

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13
Q

SHH (skin)

A

BCCa

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14
Q

34year old white F for moles that have become darker, larger, more numerous.
PE: chloasma and linea nigra present. 15 pigmented macules present; all

A

achrocordons (skin tag/fibroepithelial polyp)

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15
Q

Change in size and color during pregnancy

A 
achrocordons (fibrepithelial polyp/skin tag)
melanocytic nevi (pigmented nevus, mole)
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16
Q

genetic abnormaltiy of myxoid

A

…??

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17
Q

eccrine poroma location

A

sweat glands

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18
Q

pilar cyst or wen

A

epithelial or follicular inclusion cyst

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19
Q

69 year old farmer with male baldness with lesion on top of his head.
PMH: orthotopic cardiac transplant at 60yo for hypertrophic cardiomyopathy
PE: well healed scars from prior sclap excicional biopsies. Red-tan, nodular and centrally ulcerated 14cm lesions on scalp. SCattered red/tan hyperkaratotic lesions on face, scalp, arms.
Biopsy of nodular mass reveals atypical polygonal cells with intercellular bridges extending into dermis and involving lymphtics.

A

Squamous cell carcinoma

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20
Q

risk factors for SCCa

A
  • immunosuppression (transplant)

- ionizing radiation (**UV light –> DNA damage)

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21
Q

urticaria pigmentosa, darier sign (wheal/erythema/edema), dermatographism (“skin drawing”)

A

mastocytosis

22
Q

KIT

A

Mastocytosis, AML, GIST, hematologic diseases

23
Q

Characteristic storiform (swirling) alignment of spindle cells (skin)

A

Dermatofibrosarcoma protuberans (DFSP)

24
Q

TP53 (skin)

A

squamous cell carcinoma

25
Q

Precursor lesions to SCCa skin

A 
AK's (TLRs)
Epidrermodysplasia verriciformis (HPV)
Xeroderma pigmentsum (pyrimidine dimers)
Lichen planus (chronic inflammation)
26
Q

SEE MOLECULAR SLIDE FROM DOBSON

SEE SYNDROMES/SIGNS FROM DOBSON

A

FOR CHAPTER 25!!!

FOR CHAPTER 25

27
Q

19year old female for multiple macules.

  • PMH: ovarian fibroma with ascites and hydrothorax.
  • PE: multiple pearly papules, some appear pigmented. Vascular telangiectasia. Some erythematous and ulcerated. Multifocal islands of basophilic cells in a mucinous matrix. Periphery palisading.
  • What does she have?
  • What germline mutation?
A

PTCH (Nevoid BCCa Syndromes or Gorlin syndrome)

28
Q

table 25-3:
NBCCasyndrome
cowden
Femailial

29
Q

**BRAF (skin)

LoF CDKN2A

A

melanocytic lesions

30
Q

FGFR3 (two entities)

A

seborrheic keratosis

acanthosis nigricans

31
Q

FGFR3, IGFR1, TGF-alpha

A

acanthossi nigricans

32
Q

PTEN

trichilmmomas and breast/endometrial/other Cancers

33
Q

CYLD

A

brooke spiegler

34
Q

CTNNB1

A

pilomatricoma

35
Q

***TLRs

A

actinic keratosis (horns!)

36
Q

TP53

37
Q

**SHH/PTCH

38
Q

**PDGF-beta

COL1A1

A

Dermofibrosarcoma protuberans

39
Q

KIT

A

mastocytosis

40
Q

TNF

A

psoriasis (and HLA-C)

41
Q

TLR2

42
Q

dysplastic nevus syndrome has high risk of ___.

43
Q

Leser Trelat sydrome is…

A

sudden appearance of Seborrheic keratosis and paraneoplastic syndrome is

44
Q

Birt-Hogg-Dube syndrome is…

A

fibroeptihelial polyps and perifollicular mesenchymal tumors

45
Q

trichoepithelioma and cylindroma (CYLD mutation) is ___syndrome

A

brooke-spigler syndrome

46
Q

Muir-Torre syndrome is what two thigng?

A

internal malignancy (Hereditary NonPolyposis Colorectal Carcinoma syndrome) and sebaceous adenoma

47
Q

BCCa’s and other tumors (ovarian fibroma, medulloblastoma)

A

Gorlin/NBCCS/Basal cell nevus

48
Q

mycosis fungoides with blood involvement = ___sundrome

A

Sezary sydrome

49
Q

dermal edema and erythema (wheal) after rubbing lesion in mastocytosis is ___sign

A

darier sign

50
Q

febrile form of erythema multiforme

51
Q

ausptiz sign

A

punctate bleeding in psoriasis when scale is lifted

MSK 2 (14 decks)

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