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MSK 2 - AH > Skin - Dobson > Flashcards

Skin - Dobson Flashcards

1
Q

Honey-colored crust of pustules in children is what?

Caused by what?

The bacterial toxin produced cleaves what?

Characteristic morphology>

A

Impetigo

S. Aureus

Desmoglein 1

Accumulation of neutrophils beneath the stratum corneum

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2
Q

Acanthosis nigricans has mutation in what?

Inheritance?

What cancer may it cause?

A

FGFR3 and increased IGFR1 signaling

AD

GI adenocarcinoma

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5
Q

What stains (+) for mast cell tryptase and KIT?

A

Mastocytosis

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7
Q

Eczema from drugs has what morphology?

A

Lymphatic infiltrate w/eosinophils

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8
Q

Ulcerations of bullous vesicles around the mouth commonly seen in kids is most likely what?

A

Erythema multiforme

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10
Q

Dermatophytes are rich in what? Stain what?

Which form is caused by a yeast, Malassezia furfur?

A

MPS, PAS(+)

Tinea versicolor

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12
Q

Pink-tan-brown nodule that may be pruritic and blister that occurs in 1 year old is what?

A

Solitary mastocytoma

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13
Q

What adnexal tumor occurs on lower eyelids?

On palms and soles?

A

Syringoma

Eccrine poroma

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14
Q

What type of uticaria is triggered by factors that increase vascular permeability?

What main factor?

What mutation causes hereditary angioneurotic edema?

A

Mast cell independent
IgE independent

ASA

C1 inhibitor

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15
Q

seborrheic keratoses that appear in large numbers as part of a neoplastic syndrome is called what?

Due to what?

A

Lesser-Trelat sign

Gi tract carcinoma

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17
Q

A portion of the epidermis, including the stratum corneum forms the roof in what blister type?

What special feature?

A

Pemphigus vulgaris

Most common

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18
Q

Soft, flesh colored, slender stalk and benign squamous epithelium seen in middle-aged and older pts is what?

A

Fibroepithelial polyp aka acrochordon, squamous papilloma, skin tag

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20
Q

Uticaria is most often a result of what mast cell and IgE associations?

What type hypersensitivity rxn?

A

Mast cell dependent
IgE dependent

Type I

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21
Q

What referees to a localized area of dermal edema and erythema that occurs when lesional skin is rubbed?

Occurs in what?

A

Darier sign

Mastocytosis

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22
Q

Lichen planus treatment?

What persists for years?

A

Self limited, resolves in 1-2 years

Oral lesions

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24
Q

What HPV subtypes related to SCC?

A

5, 8

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25
Q

Mastocytosis w/uticaria pigmentosa occurs in who?

Prognosis?

A

Children

Poor

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28
Q

How does acute eczematous dermatitis occur?

What type hypersensitivity?

A

Antigens taken up by Langerhans cells, and UV damages them

4

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29
Q

What has morphology of flat-topped papules that form plaques highlighted by white lines (Wickham striae) and shows interface dermatitis?

A

Lichen planus

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30
Q

Mutation in dermatofibrosarcoma protuberans?

A

COL1A1

PDGFB

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31
Q

Lesion w/well-demarcated, pink to salmon-colored plaque covered by loosely adherent silver-white scale is what?

A

Psoriasis

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33
Q

What adnexal tumor is assoc. w/CYLD mutation and has apo/eccrine differentiation on the forehead or scalp and aka turban tumor?

Assoc w/what syndrome?

A

Cylindrical

Brooke-Spiegler

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34
Q

When large and rupture, these cause keratin spill into the dermis causing painful granulomatous inflammatory response?

A

Epithelial or follicular inclusion cyst (Wen)

37
Q

In a subepidermal blister, the entire epidermis separates from the dermis in what?

Auto-Ab to what?

Occurs in whom?

A

Bullous pemphigoid

BPAG2 - hemidesmosome

Elderly

38
Q

What presents as scaly, red-brown patches, raised, scaling plaques that occurs in pts > 40 y/o and may be a lymphoma of CD4+ cells?

Tx?

A

Mycosis fungoides

Steroids, UV light, chemo

40
Q

What is assoc. w/increased risk of endometrial cancer, breast cancer, and many other tumors?

Mutation?

A

Cowden

PTEN

41
Q

What is an inflammatory rx in subc adipose that affects lobules of fat or connective tissue?

What subtypes?

A

Panniculitis

Erythema nodosum and induratum

44
Q

What has morphology of round, flat, coinlike, waxy plaques, that are uniformly tan to dark brown and are benign, occur in middle-aged to older individuals?

Mutation in what?

A

Seborrheic keratosis

FGFR3

45
Q

Erythema nodosum is associated with what?

What morphology?

A

Drugs, sarcoidosis, IBD, infection (Tb, strep, cocci)

CT septae widen, septal fibrosis

46
Q

What is the most common chronic inflammatory dermatosis?

Has associations with what?

A

Seborrheic dermatitis

Parkinson’s, Malassezia, HIV

47
Q

Pemphigus are blistering disorders caused by what autoantibodies?

A

IgG against desmoglein

48
Q

The stratum corneum forms the roof of the bulla in what?

Endemic where?

what auto-Antibody>

A

Pemphigus foliaceus

Brazil

DSG1 only

49
Q

What adrenal tumor is assoc w/Muir-Torre syndrome?

What other syndrome?
Mutation?

A

Sebaceous adenoma

HNPCC
MMR

53
Q

Erythema multiforme in the febrile form with severe adverse cutaneous drug reactions is what?

Can progress to what?

A

SJS

TEN

54
Q

What occurs in middle-aged females as flushing and persistent erythema w/papules and rhinophyma?

High levels of what?

A

Rosacea

Cathelicidin

58
Q

What has morphology of flesh-colored fibrotic nodule on sectioning, most often on the trunk, w/thinned epidermis and storiform (swirling) alignment of spindle cells, in fat has a “honeycomb” appearance?

A

Dermatofibrosarcoma protuberans

59
Q

What benign tumor occurs on the legs of young and middle aged women and show morphology of pseudoepitheliomatous hyperplasia?

A

Dermatofibroma (fibrous Histiocytoma)

60
Q

What has cutaneous lesions including angiofibromas, localized leathery thickenings (shagreen patches), ash-leaf patches, and subungal fibrosis?

Inheritance?

A

Tuberous sclerosis

AD

61
Q

Erythema induratum occurs in whom?

Is what? Cause?

Morphology?

A

Adolescents, menopausal women

Primary vasculitis, unknown cause

Zones of caseous necrosis

62
Q

What tumor appears to be composed of at least partially of factor 13a (+) dermal DCs?

A

Dermatofibroma (fibrous histiocytoma)

63
Q

What is has an autoimmune basis and strong assoc w/HLA-Cw*0602?

What Pathogenesis?

A

Psoriasis

CD4 Th1 and Th17 cells
activated CD8 cells

64
Q

Psoriatic lesions or lichen planus induced by local trauma is what?

A

Koebner phenomenon

69
Q

What adnexal tumor assoc w/CTNNB1 mutation?

A

Pilomatricoma

71
Q

What conditions may cause erythema multiforme?

A

Infection (HSV, histo, cocci, leprosy, typhoid)
Drugs (sulfa, PCN)
Cancer
Collagen vascular disease (SLE, PAN)

73
Q

Neutrophils forming aggregates w/in Spongiform pustules and Munro microabscesses are seen in what?

A

Psoriasis

74
Q

What occurs in males 30-40 as uticaria and grouped vesicles and shows granular deposits of IgA on IF?

What disease association?

A

Dermatitis herpetiformis

Celiac

79
Q

What occurs in 10-15% as oral lesions but may also present on the flexor forearms, axilla, groin, and lower abdomen?

Ruptures? Healing? Filled w/what?

A

Bullous pemphigoid

Not easily, w/out scarring, clear fluid

83
Q

Acute lesions of skin last how long?

Chronic?

A

Days to weeks

Months to years

84
Q

Yellow, greasy fissures, w/follicular lipping is seen in what?

A

Seborrheic dermatitis

87
Q

Colloid or Civatte bodies in what?

What are they?

A

Lichen planus

Anucleate necrotic basal cells w/in inflamed papillary dermis

89
Q

Direct degranulation due to opiates, antibiotics, curare, and contrast dye causes what type of uticaria?

A

Mast cell dependent

IgE independent

91
Q

Pitting changes of nails seen in what?

15% of pts may also have what?

A

Psoriasis

Arthritis

93
Q

What is described by edema seeping into intracellular spaces of the stratum spinosum in the epidermis?

Shearing of what results in intraepidermal vesicles?

Occurs in what condition?

A

Spongiosis

Desmosomes

Acute eczematous dermatitis

96
Q

What shows morphology of the stratum granulosum thinned or absent, w/extensive overlying parakeratotic scale seen?

A

Psoriasis

97
Q

Target lesions in the hands is what?

What pathogenesis?

A

Erythema multiforme

CD8+ CTLs

MSK 2 - AH (7 decks)

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