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MSK 2 - AH > Skin - Dobson > Flashcards

Skin - Dobson Flashcards

1
Q

Honey-colored crust of pustules in children is what?

Caused by what?

The bacterial toxin produced cleaves what?

Characteristic morphology>

A

Impetigo

S. Aureus

Desmoglein 1

Accumulation of neutrophils beneath the stratum corneum

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2
Q

Acanthosis nigricans has mutation in what?

Inheritance?

What cancer may it cause?

A

FGFR3 and increased IGFR1 signaling

AD

GI adenocarcinoma

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5
Q

What stains (+) for mast cell tryptase and KIT?

A

Mastocytosis

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7
Q

Eczema from drugs has what morphology?

A

Lymphatic infiltrate w/eosinophils

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8
Q

Ulcerations of bullous vesicles around the mouth commonly seen in kids is most likely what?

A

Erythema multiforme

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10
Q

Dermatophytes are rich in what? Stain what?

Which form is caused by a yeast, Malassezia furfur?

A

MPS, PAS(+)

Tinea versicolor

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12
Q

Pink-tan-brown nodule that may be pruritic and blister that occurs in 1 year old is what?

A

Solitary mastocytoma

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13
Q

What adnexal tumor occurs on lower eyelids?

On palms and soles?

A

Syringoma

Eccrine poroma

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14
Q

What type of uticaria is triggered by factors that increase vascular permeability?

What main factor?

What mutation causes hereditary angioneurotic edema?

A

Mast cell independent
IgE independent

ASA

C1 inhibitor

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15
Q

seborrheic keratoses that appear in large numbers as part of a neoplastic syndrome is called what?

Due to what?

A

Lesser-Trelat sign

Gi tract carcinoma

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17
Q

A portion of the epidermis, including the stratum corneum forms the roof in what blister type?

What special feature?

A

Pemphigus vulgaris

Most common

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18
Q

Soft, flesh colored, slender stalk and benign squamous epithelium seen in middle-aged and older pts is what?

A

Fibroepithelial polyp aka acrochordon, squamous papilloma, skin tag

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20
Q

Uticaria is most often a result of what mast cell and IgE associations?

What type hypersensitivity rxn?

A

Mast cell dependent
IgE dependent

Type I

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21
Q

What referees to a localized area of dermal edema and erythema that occurs when lesional skin is rubbed?

Occurs in what?

A

Darier sign

Mastocytosis

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22
Q

Lichen planus treatment?

What persists for years?

A

Self limited, resolves in 1-2 years

Oral lesions

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24
Q

What HPV subtypes related to SCC?

A

5, 8

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25
Q

Mastocytosis w/uticaria pigmentosa occurs in who?

Prognosis?

A

Children

Poor

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28
Q

How does acute eczematous dermatitis occur?

What type hypersensitivity?

A

Antigens taken up by Langerhans cells, and UV damages them

4

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29
Q

What has morphology of flat-topped papules that form plaques highlighted by white lines (Wickham striae) and shows interface dermatitis?

A

Lichen planus

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30
Q

Mutation in dermatofibrosarcoma protuberans?

A

COL1A1

PDGFB

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31
Q

Lesion w/well-demarcated, pink to salmon-colored plaque covered by loosely adherent silver-white scale is what?

A

Psoriasis

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33
Q

What adnexal tumor is assoc. w/CYLD mutation and has apo/eccrine differentiation on the forehead or scalp and aka turban tumor?

Assoc w/what syndrome?

A

Cylindrical

Brooke-Spiegler

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34
Q

When large and rupture, these cause keratin spill into the dermis causing painful granulomatous inflammatory response?

A

Epithelial or follicular inclusion cyst (Wen)

37
Q

In a subepidermal blister, the entire epidermis separates from the dermis in what?

Auto-Ab to what?

Occurs in whom?

A

Bullous pemphigoid

BPAG2 - hemidesmosome

Elderly

38
What presents as scaly, red-brown patches, raised, scaling plaques that occurs in pts > 40 y/o and may be a lymphoma of CD4+ cells? Tx?
Mycosis fungoides Steroids, UV light, chemo
40
What is assoc. w/increased risk of endometrial cancer, breast cancer, and many other tumors? Mutation?
Cowden PTEN
41
What is an inflammatory rx in subc adipose that affects lobules of fat or connective tissue? What subtypes?
Panniculitis Erythema nodosum and induratum
44
What has morphology of round, flat, coinlike, waxy plaques, that are uniformly tan to dark brown and are benign, occur in middle-aged to older individuals? Mutation in what?
Seborrheic keratosis FGFR3
45
Erythema nodosum is associated with what? What morphology?
Drugs, sarcoidosis, IBD, infection (Tb, strep, cocci) CT septae widen, septal fibrosis
46
What is the most common chronic inflammatory dermatosis? Has associations with what?
Seborrheic dermatitis Parkinson's, Malassezia, HIV
47
Pemphigus are blistering disorders caused by what autoantibodies?
IgG against desmoglein
48
The stratum corneum forms the roof of the bulla in what? Endemic where? what auto-Antibody>
Pemphigus foliaceus Brazil DSG1 only
49
What adrenal tumor is assoc w/Muir-Torre syndrome? What other syndrome? Mutation?
Sebaceous adenoma HNPCC MMR
53
Erythema multiforme in the febrile form with severe adverse cutaneous drug reactions is what? Can progress to what?
SJS TEN
54
What occurs in middle-aged females as flushing and persistent erythema w/papules and rhinophyma? High levels of what?
Rosacea Cathelicidin
58
What has morphology of flesh-colored fibrotic nodule on sectioning, most often on the trunk, w/thinned epidermis and storiform (swirling) alignment of spindle cells, in fat has a "honeycomb" appearance?
Dermatofibrosarcoma protuberans
59
What benign tumor occurs on the legs of young and middle aged women and show morphology of pseudoepitheliomatous hyperplasia?
Dermatofibroma (fibrous Histiocytoma)
60
What has cutaneous lesions including angiofibromas, localized leathery thickenings (shagreen patches), ash-leaf patches, and subungal fibrosis? Inheritance?
Tuberous sclerosis AD
61
Erythema induratum occurs in whom? Is what? Cause? Morphology?
Adolescents, menopausal women Primary vasculitis, unknown cause Zones of caseous necrosis
62
What tumor appears to be composed of at least partially of factor 13a (+) dermal DCs?
Dermatofibroma (fibrous histiocytoma)
63
What is has an autoimmune basis and strong assoc w/HLA-Cw*0602? What Pathogenesis?
Psoriasis CD4 Th1 and Th17 cells activated CD8 cells
64
Psoriatic lesions or lichen planus induced by local trauma is what?
Koebner phenomenon
69
What adnexal tumor assoc w/CTNNB1 mutation?
Pilomatricoma
71
What conditions may cause erythema multiforme?
Infection (HSV, histo, cocci, leprosy, typhoid) Drugs (sulfa, PCN) Cancer Collagen vascular disease (SLE, PAN)
73
Neutrophils forming aggregates w/in Spongiform pustules and Munro microabscesses are seen in what?
Psoriasis
74
What occurs in males 30-40 as uticaria and grouped vesicles and shows granular deposits of IgA on IF? What disease association?
Dermatitis herpetiformis Celiac
79
What occurs in 10-15% as oral lesions but may also present on the flexor forearms, axilla, groin, and lower abdomen? Ruptures? Healing? Filled w/what?
Bullous pemphigoid Not easily, w/out scarring, clear fluid
83
Acute lesions of skin last how long? Chronic?
Days to weeks Months to years
84
Yellow, greasy fissures, w/follicular lipping is seen in what?
Seborrheic dermatitis
87
Colloid or Civatte bodies in what? What are they?
Lichen planus Anucleate necrotic basal cells w/in inflamed papillary dermis
89
Direct degranulation due to opiates, antibiotics, curare, and contrast dye causes what type of uticaria?
Mast cell dependent | IgE independent
91
Pitting changes of nails seen in what? 15% of pts may also have what?
Psoriasis Arthritis
93
What is described by edema seeping into intracellular spaces of the stratum spinosum in the epidermis? Shearing of what results in intraepidermal vesicles? Occurs in what condition?
Spongiosis Desmosomes Acute eczematous dermatitis
96
What shows morphology of the stratum granulosum thinned or absent, w/extensive overlying parakeratotic scale seen?
Psoriasis
97
Target lesions in the hands is what? What pathogenesis?
Erythema multiforme CD8+ CTLs

MSK 2 - AH (7 decks)

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