Bones, Joints, ST - Joe Flashcards
R.A. Produces autoantibodies to what?
CCPs/Self antigens (alpha enolase, vimentin, fibrinogen, type 2 collagen)
Rheumatoid cutaneous nodules show what morphology?
Fibrinoid necrosis w/palisading histiocytes
Pts w/gout may have a polymorphism in what?
URAT1 and GLUT9
What is a mass of edematous synovium, inflammatory cells, granulation tissue, fibroblasts that grows over articular cartilage and causes erosion?
Seen in what?
Pannus
R.A.
Hereditary variant of pseudogout is what inheritance?
Mutation in what?
AD
Pyrophosphate channel
What shows the radiology of juxta-articular bone erosion caused by osteoclastic bone resorption and loss of joint space?
Gout
Long term complications of R.A.?
Systemic amyloidosis
Caplan syndrome
ACD
Felty syndrome
Inflamed joints show which inflammatory mediators in R.A.?
TNF from Th17
IL-17 from Th17
IFN-G from Th1
CFs of OA?
Asymmetric joint involvement
Bow legged
Joint space narrowing
Prominent osteophytes
What shows pathologic change in ligamentous attachments not synovium?
What association?
Ankylosing spondylitis (Marie-Strumpell)
HLA-B27 and IL-23R gene
What causes episodes of arthritis that wax and wane for weeks to 6 months?
CFs?
Reactive arthritis
Synovitis of digital tendon sheath
What is Caplan syndrome?
R.A.
Intrapulmonary nodules w/in lungs
Pneumoconiosis
What has morphology of chondrocytes form clusters (cloning), form loose bodies, fibrillation of articular cartilage, eburnation of articular surface?
Osteoarthritis (OA)
What is Felty syndrome?
R.A.
Splenomegaly
Neutropenia
Pseudo-Gout is called what else?
Occurs in whom?
Morphology?
What joint most commonly affected?
Chondrocalcinosis (CPPD)
Older than 50, 60% older than 85
(+) birefringence, rhomboid shaped crystals
Knee
What are 2 specific findings in R.A.?
1 antibodies against citrullinated peptides (fibrinogen, type II collagen, vimentin)
RF (serum IgM or IgA autoAbs that bind to Fc portion of their own IgG)
CF of R.A.?
Pain and stiffness in morning, improves w/use
Symmetric
Small joints affected first
What is the swan-neck deformity?
Hyperextension of PIP joints
Flexion of DIP joints
What can trigger autoimmune reactions in R.A.?
Smoking
Infection
What causes arthropathy in the peripheral and axial joints, ligaments and tendons?
What special sign?
Psoriatic arthritis
Pencil in cup
What are pathognomonic for gout?
Tophi - large aggregates of urate crystals surrounded by intense inflammatory rxn
What GU infection can activate reactive arthritis?
GI?
Chlamydia
Shigella, salmonella, Yersenia, Campylobacter
What are RF for gout?
Thiazide diuretic
Tumor lysis syndrome
Common age group and sex for R.A.?
What allele?
gene mutation?
20-40, women
HLA-DRB1
PTPN22
