Skin disorders Flashcards

1
Q

Pemphigus vulgaris

A

IgG antibody against desmoglein
IF = reticular antibodies around epidermal cells
+ nikolsky sign (separation of epidermis upon manual stroking of skin)

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2
Q

bullous pemphigoid

A

IgG against hemidesmosomes = (bullow the epidermis)

IF = linear pattern at epidermal-dermal junction

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3
Q

dermatitis herpetiformis

A

IgA deposition at tips of dermal papillae –> associated w/ celiac disease

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4
Q

erythema multiform asociations

A

1) mycoplasma pneumonaie / HSV
2) drugs = sulfa drugs, B-lactams, phenytoin
3) cancers / autoimmune

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5
Q

Stevens Johnson syndrome

A

1) fever
2) bulla formation / necrosis
3) sloughing of skin
4) high mortality rate
can evolve to toxic epidermal necrolysis

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6
Q

erythema nodosum

A

painful, inflammatory lesions of subcutaneous fat –> on anterior shins
-idiopathic, associated w/ sarcoidosis, coccidiodomycosis, histoplasmosis, TB, streptococcal infections, leprosy, crohn disease

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7
Q

lichen planus

A

1) pruritic
2) purple
3) polygonal planar papules / plaques
4) associated w/ hep C

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8
Q

lichen planus on histo

A

sawtooth infilitrate of lymphocytes at dermal-epidermal junction, associated w/ Hep C

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9
Q

basal cell carcinoma

A

1) rolled borders
2) central crusting / ulceration
3) seen as “palisading nuclei” on histology

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10
Q

squamous cell carcinoma

A

2) ulcerative lesions w/ frequent scale
2) chronic draining sinuses
3) keratin pearls on histology

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11
Q

mlanoma

A

S100 tumor marker
BRAF kinase mutation
vemurafenib = BRAF kinase inhibitor

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