Skin Disoders - Reactive Disorders And Drug Eruptions

Question 1

Urticaria

Answer 1

•allergic and idiopathic forms
•IgE mediated
Anaphylaxis
Laryngeal edema, bronchospasm, shock, death
•transient wheals that resolve within 24 hours
•lesions migrate, can be associated with angioedema
•Histology: dermal edema, neutrophils, eosinophils
•Principles of Therapy: antihistamine, systemic corticosteroids, epinephrine

Question 2

Morbilliform Drug Reactions

Answer 2

• measles like diffuse and erythematous symmetric papular eruptions
• 5 days to get sensitised to new drug
• can occur from re-introduction of a previous drug
• Histology: perivascular lymphocytes
• Principles of Therapy: eliminate the drug based on probabilities

Question 3

DRESS

Answer 3

•Drug Reaction with Eosinophils and Systemic Symptoms
•rare, severe, drug induced hypersensitivity reaction
*fever, rash, lymphadenopathy, facial swelling, organ involvement (liver, kidney, lung)

Question 4

Erythema Nodosum

Answer 4

• tender erythematous nodule son anterior lower legs
• women 20-30
• associated with infections or drugs, IBD, sarcoidosis, Hodgkin’s Disease
• Histology: inflammation of fibrous septa between fat lobules
• Principles of Therapy: eliminate cause