Skin Conditions of Childhood Flashcards
What are two dermatological conditions that pharmacists should be more aggressive in regarding therapy?
Eczema and Acne
In acne, what should be the starting point for acne treatment as of now?
Almost a defacto starting point for combination therapy
- BP combomination with a retinoid
- Retinoid with an antibiotic
When would mono-therapy for acne be appropriate for acne?
Only time to use a single agent would be in the mildest case of acne possible
What is a major difference in the treatment of acne between the USa and Canada?
Differin - Adapalene
- OTC in the USA; not CAnada
Should be used by more children; need to be more aggressive with therapy here
Describe the available strengtbs of benzyl peroxide and if they are OTC or not
OTC –> 2.5-5%
Rx –> 10%
Indication of Benzyl peroxide
Solo for mild acne (rare)
Combination for moderate acne
Describe the mechanism of action of benzyl peroxide?
Anti-bacterial action - Delievers a blast of oxygen and decreases P. acnes
Exfoiliant Action = Mild surface peeling - Closed comedos open up and have less build up
How long should benzyl peroxide be trialled before a benefit may be seen?
3 months of a try to ramp up
What is the most common formulation of benzyl peroxide? Issue on this front?
Gels and lotions are the most common
BP Lotion - 6-8 hours of contact time
BP Washed - 15 hours of contact; washes may be more valuable than once thought
Do not need soap/wash and lotion/gel –> Only one BP product required
BP Washes - Benzac Wash (4 or 5%) - Not enough contact time; new reports coming out that may be more effective than once thought
–> Can go to BID-TID
Old Thinking –> More redness; OD to start and then BID-TID after a month
What are some common adverse effects of Benzoyl peroxide?
Redness, peeling, dryness, burning, bleaches clothes
Describe the role of spot treatment in acne?
Acne Patches:
- People report that they love them and say they “work”
- Astringent in there
- 4 or 5 versions; can be useful
Emergency Skin Patch - Okay
Emergency benzoyl peroxide should not be used
–> SPOT TREATMENT is still not effective
In acne, what is a cornerstone of therapy for everyone?
Normal skin care should be included in therapy
Skin Cleansing BID
Describe the indication of retinoids in acne?
Very effective topical agents
First-line agent or added to others
Describe the mechanism of action of retinoids?
Decrease the cohesiveness of the follicular wall
Increases the penetration of other agents
Vitamin A derivatives - reduce follicular stickness by retinoid receptors
Describe the avilable retinoids and there main adverse effects
Adapelene - least irritating
Tretinoin - Most photosensitizing
Taxarotene - Most potent
How can retinoids be dosed in acne?
Choose a formulation (examples: tretinoin 0.01% or 0.025% cream or 0.025% gel and 0.05% gel)
Start low and then assess in 2 months
Dose HS (photosensitive agents)
Skin needs to be dry prior to application
Pea-sized amount - disappear on skin in 1 min
Critical Counselling Point with Retinoids
Initial worsening of acne
Bring out everything clogging the pores that are hiding underneath
How can one apply benzoyl peroxide and retinoid in acne? Exceptions?
Apply retinoid at night
Apply BP during the day
–> Tretinoin and BP at same time –> D.I. and phosotosensitivity issue
BP can degrade (oxidize) tretinoin if used simulataneously, but this does not occur wjen using micronized tretinoin gel
–> patient could use both at HS
Adapalene and BP Combo Product - Tactupump - AVoids drug inetraction
What type of condition is diaper rash?
Irrirant contact dermatitis
Self-limiting - Episodes last approximately 2-3 days
Where does diaper rash commonly affect?
Only affects areas where diarhhea splashes
Skin folds are typically spared
What are some causes of diaper rash?
Fecal/urine contact –> Viral gastroenteritis ( stomach flu) leads to harsh diarhhea and harsh GI enzymes in the feces
Chemical residue (laundry detergent, wipes)
Chaffing
Antibiotic - Diarhhea as s/e
Formula more problematic than breast milk
What are some differentials f diaper rash?
Eczema - Typpically on face; not diaper area
Impetigo - Different presnetation, splotches
How can diaper rash be prevented?
Change diapers as quickly as possible
Keep the area clean
Barrier products - Tx and rotection - Vaseline
Describe the treatment of diaper rash
Keep the area clean
USe a barrier product at every diaper change
Allow air time
Steroid cream can be used