Skin and temperature control Flashcards

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1
Q

What is normal core body temp?

A

normally 37 ± 0.5°C

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2
Q

Describe the differences between central and peripheral thermoreceptors

A

Peripheral thermoreceptors
• Located in the skin, especially in face, scrotum
Central thermoreceptors
• Located in spinal cord, abdominal organs, hypothalamus

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3
Q

How does the body generate heat when you’re cold?

A

General metabolism
• Oxidative phosphorylation and other chemical reactions are not 100% efficient

Voluntary muscular activity
• “Futile” muscular activity e.g. rubbing hands etc

Shivering thermogenesis
• Involuntary muscular activity to produce heat

Non-shivering thermogenesis
• In humans, only significant in infants, due to brown adipose tissue

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4
Q

How does the body reduce heat loss when you’re cold?

A

Vasomotor control
• Sympathetic arteriolar constriction reduces delivery of blood to the skin

Behavioural responses
• Reducing surface area, adding clothing, moving to warmer environment

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5
Q

Define hypothermia

A

A fall in deep body temperature to below 35ºC

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6
Q

Who are those at risk of hypothermia?

A

Neonates - big SA:volume, not much fat, don’t shiver well, but do have BAT

Elderly - do not detect temp change so well, less shivering capacity, more immobile

Vagrants – homeless individuals

Cold store workers

Outdoor pursuits

North Sea workers

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7
Q

How do you treat hypothermia?

A

– Dry/insulate to prevent further heat loss
– Slow re-warming with bag/blankets
– Internal re-warming with hot drinks and/or warm air
– Fast re-warming by immersion in water

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8
Q

What is involved in the pathology of frostbite?

A
Vascular component
•	Vasoconstriction
•	Increase in viscosity of blood as it chills
•	Promotes thrombosis
•	Causes anoxia

Cellular component
• Ice crystals form in extracellular space
• Increases extracellular osmolality
• Causes movement of water from intracellular space
• Cell dehydration and death

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9
Q

How does the body reduce head production when they become too hot?

A

o Decreased physical activity

o Decreased food intake

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10
Q

How does the body increase heat loss when they’re warm?

A

Vasomotor control
• Arteriolar dilation increases delivery of blood to the skin

Sweating
• Sympathetic cholinergic fibres increase evaporative heat loss

Behavioural responses

Increasing surface area, removing clothing, moving to shaded area

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11
Q

Describe heat exhaustion

A

– Body temperature raised in range 37.5-40ºC

– Results in vasodilation and drop in central blood volume

– Caused by a disturbance of the body’s fluid/salt balance due to excessive sweating

– Symptoms include headache, confusion, nausea, profuse sweating, clammy skin, tachycardia, hypotension, weak pulse, fainting & collapse

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12
Q

Describe heat stroke

A

– Body temperature raised above 40ºC

– Body’s temperature control mechanisms fail

– Symptoms include hot dry skin (sweating ceased) and circulatory collapse

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13
Q

When does heat exhaustion become heat stroke?

A

When body temperature raises above 40ºC

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14
Q

Who are those at most risk of heat stress?

A

– Neonates and the elderly

– People doing physical work in hot humid environments

– Workers wearing non-breathable protective clothing e.g. fireman

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15
Q

How do you treat heat stress?

A
–	Move to cool environment 
–	Remove clothing
–	Fan
–	Sponge with tepid water
–	Give fluids (oral, intravenous)
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16
Q

What causes fever?

A

• Part of the body’s mechanism for fighting infection
• Caused by endogenous pyrogens (IL-1, IL-6)
• Concept of ‘set point’ controlled by the hypothalamus
– Endogenous pyrogens shift the set point to turn it up
– Caused by local production of prostaglandins by cyclo-oxygenase (COX) in the hypothalamus

17
Q

What drugs reduce fever?

A

aspirin & paracetamol - inhibit COX