Skin and Soft Tissue

Question 1

Lesion with well diferentiated adipose tissue but atypical hyperchromatic cells

Answer 1

Atypical lipomatous tumour (if cutaneous)
Well differentiated Liposarcoma if deep eg abdominal retroperitoneal

MDM2 and CDK4 positive

Question 2

Skin lesion with bundles of smooth muscle in dermis arranged haphazardly and some Fat
Nil atypia

Answer 2

Smooth muscle Hamartoma

Especially if congenital

Question 3

Features of accessory tragus and what syndrome is associated

Answer 3

Polypoid lesion in skin
Presence of vellus hairs ( hair doesn’t extend beyond upper dermis, hair follicles with terminal hair can extend to deep dermis and even subcutis)
Well differentiated cartilage in dermis/subcutis
Generally congenital

Associated with Goldenhaar syndrome
Sometimes with Treacher Collins

Question 4

Features of Chordoma

Answer 4

Dermal lesion 
Chondroid looking tissue
Nests and cords of cells
Many have vacuolated bubbly cytoplasm, physalipharous cells
Can have malignant versions

Chondrosarcoma very very rare in skin

Question 5

Painful lesions in skin

Answer 5

A angiolipoma
N neuroma
G glomus tumour
E eccrine spiradenoma
L leiomyoma

Blue bleb naevus