Gynaecology

Question 1

Clues to clear cell carcinoma

Answer 1

Mixture of patterns in same lesion or even slide
Includes tubulocystic, papillary, cribriform
Luminal mucin within small glands but no Mucinous epithelium seen
Hyaline tubules
Sometimes clear cells

Question 2

Most common Germ cell tumour

Answer 2

Dysgerminoma
Looks like seminoma
Usually lobulated or nested
Very cellular/blue
Young age
Often has yolk sac tumour associated with it.. Can do an afp and if raised should look and sample for yolk sac

Question 3

Benign tumour that can look infiltrative

Answer 3

Benign brenner tumour especially if it is a proliferative one

Small angulated irregular nests are suspicious for malignant brenner
Can also infiltrate the stroma in single cells
Malignant brenner tumour is also very rare

Question 4

Genes implicated in High grade serous

Answer 4

P53

BRCA

Question 5

Genes implicated in low grade serous

Answer 5

Mapk pathway including Braf, KRAS and ROS

Question 6

What tumour is associated with benign brenner tumour?

Answer 6

Mucinous carcinoma

Can also be seen with serous cystadenoma