Skin Flashcards
What signaling pathway sis activated when a mole is formed?
RAS
As the cells of a mole go deeper what happens to their size?
Get smaller
What is dysplastic nevi syndrome?
What are two activating mutations for dysplasic moles?
Greater than 50% chance to develop melanoma by age 60
NRAS and BRAF
Majority of melanoma causes arise in what way?
Where in the body do women most commonly have melanoma and where for men?
Sporadic
Legs for women
Upper back for males
What is the most common mutation for melanoma?
Additional mutation to know?
TERT, activate telomerase.
BRAF
How do we actually measure depth of invasion in melanoma and what is the measurement called?
Top of the granular layer in the epidermis to the deepest tumor cell
Breslow Thickness
What is the E of ABCDE of melanoma?
Evolving over time
What is the mutation in seborrheic keratoses?
FGFR3
Mutation and clinical sign of cowden syndrome?
Clinical sign of muir torre syndrome?
Mutation of NFibromatosis1 and 2?
PTEN and trichilemmonas
Sebaceous adenoma
NF1 neurofibromin and NF2 Merlin
3 mutations associated with SCC?
What infection is also implicated?
P53, RAS and notch
HPV 5 and 8
Mutation most commonly found in basal cell carcinoma?
Sonic Hedge Hog, PTCH
Mutation of dermatofibrosarcoma protuberant and common clinical presentation?
Translocation of collagen 1a1 with PDGF
Protuberant nodule from trunk
How do we characterize Mycosis Fungoides?
What is Sezary syndrome?
What are Sezary cells?
What are pautrier syndrome?
CD4 cells proliferate in the skin causing rash, plaques and nodules
Cells get in the blood and cause scaling over entire body
Cd4 T cells with cerebriform nuclei
Cells cluster in the epidermis
Genetic involvement in psoriasis?
HLACw0602
Where in the world do we see pemphigus faliacues?
What cell layer is detached in foliacues?
Brazil
Corneum
