Bone Flashcards
What are the two bone tumors found in the epiphysis?
Osteoblastoma and Giant Cell Tumor
How do most osteochondromas present?
Solitary
What is Ollier Syndrome?
What is mafucci syndrome?
Multiple chondromas
Multiple chondromas with angiomas increasing the risk for chrondrosarcoma
Two most common malignant tumors of bone?
Where does the second commonly metastasize when it is invasive?
Osteosarcoma
Chondrosarcoma
Lungs
When is pain worse for an osteoid osteoma?
By definition, how big is an osteoid osteoma?
Where are these tumors typically found in the body?
Night
Less than 2 cm
Long bones, tibia and femur
Increased risk for osteosarcoma is most common with what mutation?
What is Li Frauamani syndrome in regards to osteosarcoma?
Top 3 places osteosarcoma spread and by what mechanism (which one is most common?
RB
Osteosarcoma with p53 mutation
Lungs (Most common), bone and brain by blood.
What race do we most commonly find Ewing sarcomas in?
What is the the translocation and what does it cause?
What is an important prognostic finding in Ewing sarcoma?
White
11:22 EWS FL11 fusion gene
Chemotherapy induced necrosis
What is PNET in regards to Ewing Sarcoma?
It means it is a malignant primitive neuroectodermal tumor
How do we characterize fibrous dyplasia?
What age group do we typically see it in?
3 places in the body we find it?
Histo feature?
2 syndromes that include fibrous dyplasia?
Benign proliferation of fibrous tissue and bone Early teens Craniofacial, leg, and ribs Chinese letters McClune Albright and Mazabraud
Top 4 metastatic tumors to bone in adults?
Top 5 metastatic tumors in kids?
Prostate, breast, kidney and lung
Neuroblastoma, wilms, osteosarcoma, Ewing, and rhabdomyosarcoma
