Skin

Question 1

4 layers of epidermis?

Answer 1

Stratum corneum
S. Granulosum
S. Spinosum
S. Basale

Question 2

Cells linked by desmosomes in?

Answer 2

Stratum spinosum

Question 3

Mitosis occurs in?

Answer 3

S. Basale

Question 4

Epidermis separated from dermis by?

Answer 4

Basement membrane in Rete ridges

Question 5

Vasculature and nerves run in?

Answer 5

Dermis

Question 6

Increased keratin in the stratum corneum?

Answer 6

Hyperkeratosis

Question 7

Nuclei in the stratum corneum (usually none)

Answer 7

Paraketosis

Question 8

Acanthosis affects which layer?

Answer 8

Stratum spinosum

Question 9

Acantholysis is?

Answer 9

Disruption of cohesion between keratinocytes

Question 10

C3 and IgG attack hemidesmosomes?

Answer 10

PemphigoiD

Question 11

Nikolsky sign negative?

Answer 11

PemphigoiD

Question 12

IgG attack E cadherin causing acantholysis in?

Answer 12

PemphiguS

Question 13

Antibodies to desmoglein 1?

Answer 13

Pemphigus foliaceus

Question 14

Intercellular oedema?

Answer 14

Spongiosis

Question 15

Auspitz sign?

Answer 15

Pinpoint bleeding due to loss of granular layer in psoriasis

Question 16

Most common form of psoriasis?

Answer 16

Chronic plaque psoriasis

Question 17

Nail changes in psoriasis?

Answer 17

POSH

Pitting
Onycholysis
Subungal hyperkeratosis

Question 18

Mother of pearl sheen and pruritic purple polygonal plaques?

Answer 18

Lichen planus

• assoc wickham’s striae in mouth
• inflam of dermal-epidermal junction

Question 19

Targetoid annular lesions caused commonly by drugs reaction?

Answer 19

Erythema multiforme

Question 20

Percentage of skin detachment in:

Stevens Johnson syndrome?

Toxic Epidermal Necrolysis?

Answer 20

SJS <10%

TEN >30%

Question 21

Salmon pink rash starting with herald patch and then spreading out in fir tree pattern on trunk?

Answer 21

Pityriasis rosea

Question 22

Warty cauliflower lesion looks stuck on and waxy. Found in elderly

Answer 22

Seborrhoeic dermatitis

Question 23

Rodent ulcer
Grows SLOWLY
RARELY metastatic

Pearly surface with telamgiectasia

Answer 23

Basal cell carcinoma

Question 24

Squamous cell carcinoma?

Answer 24

Bowen’s disease has spread through BM into dermis

Question 25

Flat red scaly patches on sun exposed areas Basement membrane INTACT

Answer 25

Bowen's disease (SCC in situ)

Question 26

Most important prognostic factor for malignant melanoma?

Answer 26

Breslow thickness

Question 27

Most aggressive melanoma?

Answer 27

Nodular

Question 28

Outermost layer of skin?

Answer 28

Stratum Corneum of epidermis