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Histopath > Skin > Flashcards

Skin Flashcards

1
Q

4 layers of epidermis?

A

Stratum corneum
S. Granulosum
S. Spinosum
S. Basale

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2
Q

Cells linked by desmosomes in?

A

Stratum spinosum

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3
Q

Mitosis occurs in?

A

S. Basale

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4
Q

Epidermis separated from dermis by?

A

Basement membrane in Rete ridges

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5
Q

Vasculature and nerves run in?

A

Dermis

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6
Q

Increased keratin in the stratum corneum?

A

Hyperkeratosis

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7
Q

Nuclei in the stratum corneum (usually none)

A

Paraketosis

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8
Q

Acanthosis affects which layer?

A

Stratum spinosum

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9
Q

Acantholysis is?

A

Disruption of cohesion between keratinocytes

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10
Q

C3 and IgG attack hemidesmosomes?

A

PemphigoiD

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11
Q

Nikolsky sign negative?

A

PemphigoiD

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12
Q

IgG attack E cadherin causing acantholysis in?

A

PemphiguS

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13
Q

Antibodies to desmoglein 1?

A

Pemphigus foliaceus

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14
Q

Intercellular oedema?

A

Spongiosis

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15
Q

Auspitz sign?

A

Pinpoint bleeding due to loss of granular layer in psoriasis

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16
Q

Most common form of psoriasis?

A

Chronic plaque psoriasis

17
Q

Nail changes in psoriasis?

A

POSH

Pitting
Onycholysis
Subungal hyperkeratosis

18
Q

Mother of pearl sheen and pruritic purple polygonal plaques?

A

Lichen planus

  • assoc wickham’s striae in mouth
  • inflam of dermal-epidermal junction
19
Q

Targetoid annular lesions caused commonly by drugs reaction?

A

Erythema multiforme

20
Q

Percentage of skin detachment in:

Stevens Johnson syndrome?

Toxic Epidermal Necrolysis?

A

SJS <10%

TEN >30%

21
Q

Salmon pink rash starting with herald patch and then spreading out in fir tree pattern on trunk?

A

Pityriasis rosea

22
Q

Warty cauliflower lesion looks stuck on and waxy. Found in elderly

A

Seborrhoeic dermatitis

23
Q

Rodent ulcer
Grows SLOWLY
RARELY metastatic

Pearly surface with telamgiectasia

A

Basal cell carcinoma

24
Q

Squamous cell carcinoma?

A

Bowen’s disease has spread through BM into dermis

25
Q

Flat red scaly patches on sun exposed areas

Basement membrane INTACT

A

Bowen’s disease (SCC in situ)

26
Q

Most important prognostic factor for malignant melanoma?

A

Breslow thickness

27
Q

Most aggressive melanoma?

A

Nodular

28
Q

Outermost layer of skin?

A

Stratum Corneum of epidermis

Histopath (5 decks)

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