Skin

Question 1

What are the layers of the dermis? (-stratum)

Answer 1

SUPERFICIAL

Corneum
Lucidum
Granulosum
Spinosum
Basale

DEEP

Question 2

Which dermis layer do BCCs arise from?

Answer 2

Stratum Basale

Question 3

What is the embryological derivation of melanocytes?

Answer 3

Neural crest

It is because of this, MM is super malignant as it can spread anywhere to other neural crest tissues. BCC/SCC are localised to the epidermis because of embryology.

Question 4

How deep is the subcutaneous fat layer from surface?

Answer 4

> 4mm from surface

Question 5

How deep is the dermis layer from surface?

Answer 5

1-4 mm from surface

Question 6

How deep is the epidermis layer from surface?

Answer 6

0-1mm from surface

Question 7

What tumour marker is used for malignant melanoma?

Answer 7

LDH

Question 8

What gene mtutations are important in malignant melanoma?

Answer 8

CDKN2A
CDK4
BAP1
POT1
TERT

Question 9

What are the tumour markers important in malignant melanoma?

Answer 9

S100B
HMB45
MADT1
LDH
MIA

Question 10

What are the different types of malignant melanoma?

Answer 10

• Superficial Spreading Melanoma (most common)
• Nodular Melanoma (most likely to spread)
• Lentigo Maligna (benign) Melanoma (malignant)
• Acral Lentiginous Melanoma (more common in darker tones)
• Amelanotic Melanoma.
• Nevoid Melanoma.
• Spitzoid Melanoma.
• Desmoplastic Melanoma.
• Ocular Melanoma

Question 11

Name a neuroendocrine tumour of the skin

Answer 11

Merkel cell carcinoma