skeletal system Flashcards
define the skeletal system
consists of bones, cartilage and ligaments tightly joined to form a strong, flexible framework for the body
describe osteology
skeleton
bone is living tissue
newborn human has 350 bones
adult human has 206 bones
what are the functions of the skeletal system I
support for body and framework for attachment of soft tissues and organs
movement = attachment of skeletal muscles to bones either side of joints enable movement
protection = many soft tissues and organs surrounded by bone for protection
functions of skeletal system II
storage of minerals = calcium salts, important for maintaining normal conc of calcium and phosphate ions in body fluids
storage of lipids in areas filled with yellow marrow are important for energy reserves
blood cell production = red and wbc and other blood elements are produced in red marrow
describe bone formation and growth
ossification = formation of bone and replacing other tissues with bone
two forms:
endochrondral = bone replaces existing cartilage model
intramembranous = bone develops directly from mesenchyme or fibrous connective tissue
describe endochondral ossification
bone originates as a cartilage model
cartilage is flexible connective tissue found in many areas of body
chondrocytes are only cells found in healthy cartilage
produce and maintain cartilaginous matrix, which consists mainly of collagen
stage 1 of endochondral ossification
chondrocytes begin to increase in size while matrix calcifies around them
chondrocytes become starved then die
stage 2 of endochondral ossification
blood vessels grow into perichondrium
cells in perichondrium differentiate into osteoblasts and begin forming bone around edge of cartilage shaft
now termed = periosteum
stage 3 endochondral ossification
blood vessels and fibroblasts migrate to cartilage. fibroblasts differentiate into osteoblasts
calcified cartilage matrix breaks down and replaced by trabecular bone
site where this first occurs known as primary ossification centre
stage 4 endochondral ossification
wave of ossification spreads towards ends of long bone
osteoclasts absorb bone from centre leaving a marrow cavity
bone grows inwards from periosteum forming compact bone surrounding marrow cavity
stage 5 endochondral ossification
capillaries and osteoblasts migrate into epiphyses and ossification begins
these areas aka secondary ossification centres
timing of appearance of secondary ossification centre varies greatly
describe immature long bone
formation of trabecular bone in epiphysis leaves two areas of cartilage
articular cartilage = articulates with cartilage from another bone, prevents bone articulations
epiphyseal growth plate = allows interstitial growth in bone
growth of cartilage
interstitial growth = growth within epiphyseal growth plate
apposition growth = new layers of cartilage added to surface e.g. perichondrium
describe factors that affect bone development I
organic and mineral components of bone matrix are being recycled and renewed through process of remodelling
normal bone growth and maintenance depend on combination of environmental, nutritional and hormonal factors
factors that affect bone development II
overall shape and dimensions determined genetically
bone adapts to meet functional demands
availability of calcium, phosphate salts, vitamin ACDK and B12 essential for normal bone development