Skeletal Muscle Relaxers

Question 1

Carisoprodol

Answer 1

CNS reticular activating system & SC
CNS sedation, vision loss, mydriasis, ortho. HypoTN
No effect on NMJ
CYP2C19 & Renal.

Question 2

Cyclobenzaprine

Answer 2

TCA
CYP!, DUMBELLS, CNS sed, GI: paralytic ileus
Not effective for CNS/ spinal cord pain
QT Prolongation

Question 3

Methocarbamol

Answer 3

Indirect.. pain perception

CNS sed., headache, irritability, blurred vision

Question 4

Tizanidine

Answer 4

Presynaptic a-2 receptor agonist
Renal/elderly risk, liver, rebound hypertonicity, HTN at high dose, CNS additive, Additive hypoTN with:
Monitor LFTs
CI: clonidine, guanabenz, methyldopa, guanfacine