Gout Flashcards
1
Q
Colchicine
A
Microtubule depolarizer
Blood dyscrasia, GI
Acute
2
Q
Indomethacin
A
Cox
GI, frontal headache, liver, CI: furosemide and HCTZ
Acute
3
Q
Allopurinol
A
XOi
Increased acute attacks, HS, liver, CI: 6-MP, penicillins
4
Q
Febuxostat
A
XOi: unrelated to allo.
Mild…
More potent than allopurinol.
5
Q
Probenecid
A
PCT UA reabsorption blocker
CI: salicylates
Hydrate! Dissolves
6
Q
Pegloticase
A
PEGylated UA oxidase converts to Allantoin.
Gout flares (prophylax: colchicine/NSAID/GC)
Rapid lower, dissolves
IV only.
Antibodies can develop.
