Nsaids

Question 1

Aceteminophen

Answer 1

CNS: Cox1 and 2

GI, renal, liver

Question 2

Aspirin

Answer 2

Cox1 and 2 Covalent bond.
Irreversible: bleeding, GI, renal, liver, salicylate poison
H2 antagonist and PPI to reduce GI effect.

Question 3

Diclofenac

Answer 3

Cox1 and 2
GI, renal, liver,
HTN with ACEi and ARBs
Short half life

Question 4

Ibuprophen

Answer 4

Cox1=2
GI, renal, liver,
HTN with ACEi and ARBs
Low risk GI:1 = 2 ???

Question 5

Indomethacin

Answer 5

Cox1»2
GI, renal, liver,
HTN with ACEi and ARBs
High risk GI:1 > 2

Question 6

Ketoprofen

Answer 6

Cox1 and 2
GI, renal, liver,
HTN with ACEi and ARBs

Question 7

Ketorolac

Answer 7

Cox1 and 2
GI, renal, liver,
HTN with ACEi and ARBs

Question 8

Naproxen

Answer 8

Cox1 and 2
GI, renal, liver,
HTN with ACEi and ARBs

Question 9

Piroxicam

Answer 9

Cox1 and 2
GI, renal, liver,
HTN with ACEi and ARBs
High risk GI: long halflife

Question 10

Sulindac

Answer 10

Cox1 and 2
GI, renal, liver,
HTN with ACEi and ARBs
Hepatotoxicity: LFTs!

Question 11

Celecoxib

Answer 11

ONLY Cox2
No GI, No bleeding, No platelets
No GI!!!!!