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Undeleted > Skeletal muscle relaxants > Flashcards

Skeletal muscle relaxants Flashcards

0
Q

what drug reverses effects if Nondepolarizing NMB?

A

neostigmine

- a cholinesterase inhibitor

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1
Q

2 types of neuromuscular blockade

A

Depolarizing blockade - persistent depolarization of the end plate

Nondepolarizing blockade - antagonism at the Ach receptor of the end plate

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2
Q

ND-NMB drug with the most rapid onset

A

Rocuronium

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3
Q

ND-NMB mechanism of action

A

competitive antagonist at skeletal muscle NICOTINIC Ach receptors

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4
Q

the only ND NMB with moderate block on cardiac MUSCARINIC receptors

A

pancuronium

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5
Q

components of lethal injection

A

thiopental
pancuronium
potassium chloride

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6
Q

what is the main use of Neuromuscular blockers?

A

muscle relaxation during intubation and GA

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7
Q

neostigmine is the drug of choice for what condition?

A

myasthenia gravis

Dx: Edraphonium
Tx: Neostigmine

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8
Q

Drugs metabolized by pseudocholinesterase

A

mivacurium

succinylcholine

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9
Q

atracurium undergoes what type of elimination?

A 
Hofmann elimination
(rapid spontaneous breakdown)
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10
Q

prototype for short acting ND NMB

A

mivacurium

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11
Q

long acting ND NMB

A

tubocurarine and pancuronium

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12
Q

intermediate acting ND NMB

A

atracurium rocuronium vecuronium

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13
Q

what drug causes recurarization?

A

tubocurarine

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14
Q

ND NMB that undergoes elimination in the bile

A

vecuronium

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15
Q

What novel drug is used for rocuronium overdose?

A

Sugammadex

selective relaxant binding agent

16
Q

Drug used for Strychnine poisoning?

A

Pancuronium

17
Q

what is the only depolarizing NMB?

A

succinylcholine

18
Q

MOA of succinylcholine

A

Agonist at ACh-N receptors causing initial twitch then persistent depolarization

19
Q

Treatement for malignant hyperthermia?

A

Dantrolene

Undeleted (14 decks)

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