sjrogens syndrome .

Question 1

what is sjogrens

Answer 1

autoimmune condition that effects the exocrine glands - characterised by lymphocytic infiltrates

Question 2

pathophysiology of sjogrens

Answer 2

immune system mainly attacks lacrimal and salivary glands

Question 3

symptoms of sjogrens

Answer 3

dry eyes - gritty feeling
dry mouth - may lead to fissured tounge
dry throat
vaginal dryness
joint pains
fatigue

Question 4

signs of sjogrens

Answer 4

bilateral parotid gland enlargement

unexplained increase in dental caries

Question 5

Ix in suspected sjogrens

Answer 5

schirmers test = ocular dryness

postive anti-Ro and anti-La antibodies

lymphocytic infiltrates on lip gland biopsy

Question 6

describe schirmers test

Answer 6

paper strip inserted into the corners of the eyes for several minutes to measure tear production

Question 7

Mx of sjogrens

Answer 7

symptom control - tear and salivary replacement, analgesia, exercise

hydroxychloroquine can sometimes help with arthralgia and fatigue

immunosuppression would only be used in the context of organ involvement e.g. interstitial lung disease

Question 8

complications of sjogrens

Answer 8

inreased risk of lymphoma

peripheral neuropathy and interstitial disease

sjogrens less commonly has other organ complictaions so no monitoring