Sjorgens Syndrome Flashcards
1
Q
Pathogenesis of Sjorgens?
A
Autoimmune destruction of the lacrimal and salivary glands
Extraglandular manifestations =
- Autoimmune induced inflammation directed against ductal epithelium
- Immune complex formation
2
Q
Skin and msk manifestations of Sjorgens?
A
Xerosis Purpura Raynauds Vasculitis Arthragias Arthritis Fibromyalgia
3
Q
Other systemic manifestations of Sjorgens?
A
Dysphagia GORD Coeliac disease Raised LFTs Thyroid disease RTA ILD Peripheral neuropathy CVD Cytopenias
4
Q
Exocrine gland disease?
A
Keratoconjunctivitis sicca Xerostomia Oral candidiasis Salivary and Lacrimal gland enlargement Genitourinary dryness in women Sinusitis Lymphoma
5
Q
Diagnosis of Sjorgen’s?
A
Swollen facial glands
Dry eyes
Dry mouth
Biopsy = lymphocytic sialadenitis Raised ESR and CRP Cytopenias ANA Anti-Ro/SSA antibodies Anti-La/SSB antibodies
6
Q
Treatment of Sjorgens?
A
Tear conservation Artificial tears Topical corticosteroids for eyes Topical cyclosporine for eyes Punctal occulsion Saliva replacements Sialagogues HCQ MTX Rituximab
