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Rheumatology > Dermatomyositis and Polymyositis > Flashcards

Dermatomyositis and Polymyositis Flashcards

1
Q

Presentation of DM and PM

A

Weakness
NOT PAIN
DM = rashes and Gottron’s papules

Associated with:

  • Arthritis
  • Raynauds
  • Interstitial lung disease
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2
Q

Diagnosis

A

BIOPSY

Autoantibodies:

  • ANA
  • Jo-1
  • Anti SRP
  • Anti Mi2
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3
Q

What is the importance of Jo-1

A

Most frequent antibody seen

Interstitial lung disease
Arthropathy
Fever
Raynauds

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4
Q

Importance of Anti SRP

A

Polymyositis only

Refractory to treatment

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5
Q

Importance of Anti Mi2

A

Dermatomyositis

Shawl rash

Good treatment response

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6
Q

Histology of PM and IBM

A

Endomysial
Infiltrating muscle fibres
CD8 cells

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7
Q

Histology of DM

A

Perimysial and perivascular
Not infiltrating
CD4 cells

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8
Q

Cancer risk

A

All patients newly diagnosed should be evaluated for the possibility of an underlying malignancy

Adenocarcinomas of the cervix, lung, ovaries, pancreas, bladder, and stomach most common

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9
Q

Treatment

A 
Steroids
MTX
AZA
Cyclosporine
IVIG
Rituximab for refractory cases
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Rheumatology (10 decks)

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