Sjogrens Syndrome

Question 1

What characterises Sjogrens syndrome?

Answer 1

Lymphocytic infiltrates in exocrine organs

Question 2

Describe the symptoms of Sjogrens syndrome?

Answer 2

Sicca

• eyes
• mouth

Arthralgia
Fatigue
Vaginal Dryness
Parotid gland swelling

Question 3

Describe the onset of Sjogrens syndrome

Answer 3

Primary condition or secondary to other autoimmune conditions like RA and SLE

Question 4

How is sjogrens diagnosed?

Answer 4

Confirmation of ocular dryness- Schirmers test

Positive Anti-Ro

Positive Anti-La

Typical features of lip gland biopsy

Question 5

How is Sjogrens managed?

Answer 5

Largely management of symptoms

-lubricating eye drops

-Saliva replacement
Pilocarpine can stimulate saliva but can cause flushing

-dental care (caries)

Hydroxychloroquine can help with arthralgia and fatigue

Immunosuppresion if organ involvement

Question 6

What are the complications of sjogrens?

Answer 6

Peripheral neuropathy and interstitial lung disease

Increased risk of lymphoma