Sjogren's syndrome

Question 1

What is Sjogren’s syndrome?

Answer 1

• Autoimmune disorder affecting exocrine glands
  
  • Results in dry mucosal surfaces
• Primary (PSS) or Secondary to RA or other connective tissue disorders
• More common in females
• Increased risk of lymphoid malignancy

Question 2

Features of Sjogren’s syndrome?

Answer 2

• DARRRS
• Dry eyes, mouth and vagina
• Arthralgia
• Raynaud’s
• Recurrent parotitis
• Renal tubular acidosis
• Sensory polyneuropathy

Question 3

Investigations in Sjogren’s syndrome?

Answer 3

• Rheumatoid factor
• ANA
• Anti-Ro (SSA) antibodies
• Anti-La (SSB) antibodies
• Schirmer’s test
• Histological: focal lymphocytic infiltration

Question 4

Describe Schirmer’s test?

Answer 4

Filter paper near conjuctival sac to measure tear formation

Question 5

Management of Sjogrens syndrome?

Answer 5

• Artifical saliva and tears
• Pilocarpine
  
  • may stimulate saliva production