Sjogren's Syndrome

Question 1

Sjögren’s Definition

Answer 1

Chronic autoimmune disease characterised by inflammation of exocrine glands
1-3% prevelance
Females

Question 2

Sjögren’s Pathology

Answer 2

Cause Unknown
Lymphocyte infiltration in exocrine glands
B cell activation-> destruction and fibrosis

Question 3

Sjögren’s Ocular symptoms

Answer 3

Decreased tears and dry eyes
Sore and gritty and red
Corneal destruction

Question 4

Sjögren’s Oral symptoms

Answer 4

Deceased saliva-> dry mouth -> xerostomia
Tongue fissures
Oral candidiasis
Parotid swelling

Question 5

Sjögren’s Systemic symptoms

Answer 5

Vaginal dryness
Oesophagitis 
Fever, malaise, wt loss
Episodic arthritis 
Raynauds
Intersitial lung disease
Interstitial nephritis 
Diabetes insipidus
Peripheral neuropathy

Question 6

Sjögren’s Investigations

Answer 6

Schrimmers test-> tissue beneath lower eyelid-> doesn’t get wet

Staining of damages cornea
Raised EST
Raised Ig
Anti rolua antibodies

Question 7

Sjögren’s Management

Answer 7

Tear replacement
Canaliculi occlusion
Saliva substitutes
Good dental hygiene 
Immunosuppression