Idiopathic Inflammatory Myopathies Flashcards
1
Q
Myopathy Definition
A
Autoimmune inflammation of striated muscle
2
Q
Myopathy Epidemiology
A
2-10/million/y
40-60y
3
Q
Myopathy Pathology
A
Immune infiltration of muscle fibres -> degeneration -> necrosis -> phagocytosis Myosotis Dermatomyositis
4
Q
Clinical features myositis
A
Symmetrical proximal muscle wasting Muscle pain and tenderness Intercostals Dysphagia Waddling gait
5
Q
Clinical features dermatomyositis
A
Gottrons papules-> erythematous, scaly papules on rings Heliotrope rash Macular erythematous rash Calcinosis Cutaneous vasculitis Periungual Telangectasia Photo sensitivity
6
Q
Myopathy Extra muscular features
A
Fatigue, malaise, wt loss, fever Poly arthritis Interstitial lung disease Myocarditis GI vasculitis Underlying malignancy
7
Q
Myopathy Investigations
A
Anaemia of chronic disease Increased ESR Increase CK and serum muscle enzymes Anti Jo-1 Muscle biopsy-> inflam infiltration EMG-> muscle weakness MRI-> muscle oedema
8
Q
Myopathy Management
A
Physiotherapy
Corticosteroids
Methotrexate
Malignancy monitoring
