Antiphospholipid Syndrome Flashcards
1
Q
Antiphospholid syndrome Definition
A
Clinical syndrome characterised by a tendency to recurrent thrombosis and/or pregnancy morbidity
And persistently raised antiphospholid antibodies
2
Q
Antiphospholid syndrome Pathology
A
Lupus anticoagulant and anticardiolupin antibodies
-> procoagulant effect
Impaired fibrinolysis
Increased vascular tone
3
Q
Antiphospholid syndrome Clinical features
A
Recurrent vascular thrombosis Pregnancy morbidity -> miscarriages, pre eclampsia Thrombocytopenia Haemolytic anaemia Superficial phlebitis Mitral valve prolapse Transverse myelitis, chorea, epilepsy Migraine
4
Q
Antiphospholid syndrome Investigations
A
Serology
- anticardiolupin antibodies
- lupus anticoagulant assay
Thrombocytopenia
5
Q
Antiphospholid syndrome Management
A
Life style
- stop smoking
- avoid OCP
- treat BP, lipids, DM
A symptomatic
-no treatment
Venous/Arterial thrombosis
- life long anti coagulation
- warfarin
- heparin during pregnancy
