Sjogren's Syndrome Flashcards
What is Sjogrens Syndrome?
- Chronic autoimmune disease affecting salivary glands and tear glands
What are the 3 classifications of Sjogrens Syndrome?
- Sicca syndrome
- Primary sjogrens
- Secondary sjogrens
What is Sicca syndrome?
- Partial sjogrens findings
- Either dry eyes or dry mouth not both
What is primary sjogrens syndrome?
- Dry eyes and dry mouth
- But no other connective tissue disease
What is Secondary sjogrens syndrome?
- Dry eyes and dry mouth
- Has other Connective tissue disease
- e.g. SLE, RA, Scleroderma
What are some common triggers that when they are interlinked makes a susceptible pt more likely of developing auto-immune disease>
- Genetics
- Infections
- Dietary components
- Toxic chemicals
What is the epidemiology of sjogrens syndrome?
- 0.2-1.2% have this disease
- Half this figure have another connective tissue disease
- 10:1 women
Why is there diagnostic delay in sjogren’s syndrome?
- Late presentations of disease due to disease not causing any pain when affecting the tissues
- Most likely only get diagnosed when pt present with dry mouth, by this time the salivary glands have been too affected for thorough intervention
If sjogrens is present during reproductive phase of pregnancy what is there a risk for the baby of?
- Neonatal lupus
- Can lead to complete heart block leading baby to need pacemaker fitted later on
There is systemic involvement in secondary sjogrens syndrome. What systems are the most involved?
- Lungs
- Kidney (renal)
- Liver
- Pancreas
- Blood vessels
- Nervous
- Due to vasculitic changes due to autoimmune process
What is the sjogrens syndrome aetiology?
- Genetic predisposition (association with anti-Ro and anti-La)
- Low oestrogen gives risk of getting CT disease
- Incomplete cell apoptosis leads to antigens being improperly exposed
- Dysregulation of inflammatory process with dendritic AP cells recruiting Band T cell responses and pro-inflam cytokines
Weak evidence of EBV (epstein bar virus) association - reactive change rather than causative
What are the consequences of sjogrens syndrome?
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