Sjogren's Syndrome Flashcards

1
Q

What is Sjogrens Syndrome?

A
  • Chronic autoimmune disease affecting salivary glands and tear glands
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2
Q

What are the 3 classifications of Sjogrens Syndrome?

A
  • Sicca syndrome
  • Primary sjogrens
  • Secondary sjogrens
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3
Q

What is Sicca syndrome?

A
  • Partial sjogrens findings
  • Either dry eyes or dry mouth not both
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4
Q

What is primary sjogrens syndrome?

A
  • Dry eyes and dry mouth
  • But no other connective tissue disease
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5
Q

What is Secondary sjogrens syndrome?

A
  • Dry eyes and dry mouth
  • Has other Connective tissue disease
  • e.g. SLE, RA, Scleroderma
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6
Q

What are some common triggers that when they are interlinked makes a susceptible pt more likely of developing auto-immune disease>

A
  • Genetics
  • Infections
  • Dietary components
  • Toxic chemicals
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7
Q

What is the epidemiology of sjogrens syndrome?

A
  • 0.2-1.2% have this disease
  • Half this figure have another connective tissue disease
  • 10:1 women
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8
Q

Why is there diagnostic delay in sjogren’s syndrome?

A
  • Late presentations of disease due to disease not causing any pain when affecting the tissues
  • Most likely only get diagnosed when pt present with dry mouth, by this time the salivary glands have been too affected for thorough intervention
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9
Q

If sjogrens is present during reproductive phase of pregnancy what is there a risk for the baby of?

A
  • Neonatal lupus
  • Can lead to complete heart block leading baby to need pacemaker fitted later on
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10
Q

There is systemic involvement in secondary sjogrens syndrome. What systems are the most involved?

A
  • Lungs
  • Kidney (renal)
  • Liver
  • Pancreas
  • Blood vessels
  • Nervous
  • Due to vasculitic changes due to autoimmune process
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11
Q

What is the sjogrens syndrome aetiology?

A
  • Genetic predisposition (association with anti-Ro and anti-La)
  • Low oestrogen gives risk of getting CT disease
  • Incomplete cell apoptosis leads to antigens being improperly exposed
  • Dysregulation of inflammatory process with dendritic AP cells recruiting Band T cell responses and pro-inflam cytokines

Weak evidence of EBV (epstein bar virus) association - reactive change rather than causative

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12
Q

What are the consequences of sjogrens syndrome?

A

10mins in

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