Sites of action Flashcards
Which antimicrobials act by disrupting cell wall synthesis?
- cycloserine
- vancomycin, teichoplanin
- bacitracin
- penicillins
- cephalosporins
- monobactams
- carbapenems
Which antimicrobials disrupt folic acid metabolism? specifically where
trimethoprim => blocks DHFA from converting to THFA
sulfonamides => blocks PABA from converting to DHFA
Which antimicrobials act at the periplasmic space?
- B-lactamases
- aminoglycoside-modifying enzymes
Which antimicrobials distrupt the cell membrane?
polymyxins
Which antimicrobials affect protein synthesis via the tRNA?
mupirocin
What antimicrobial acts in the cytoplasm nonspecifically?
chloramphenicol tranacetylase
Which antimicrobials are 30s inhibitors and thus block protein synthesis?
- tetracycline
- spectinomycin
- streptomycin
- gentamicin
- tobramycin (aminoglycoside)
- amikacin
Which antimicrobials block protein synthesis by binding to 50s inhibitors?
erythromycin (macrolides)
choramphenicol
clindamycin
Which antimicrobials disrupt DNA-directed RNA polymerase?
rifampin
Which antimicrobials disrupt DNA gyrase?
quinolones
