Antifungal agents=> general and systemic Flashcards
antifungal drugs presently available fall into the following categories: (name type of drug and infection)
systemic drugs (oral or parenteral) for systemic infections,
oral systemic drugs for mucocutaneous infections,
topical drugs for mucocutaneous infections.
What are the drug classes for systemic infections?
amphotericin b
Echinocandins
What produces Amphotericin B?
it is an antifungal antibiotic produced by Streptomyces nodosus
How is amphotericin B prepared?
a colloidal suspension of amphotericin B nd sodium desoxycholate for IV injection
How would you deliver amphotericin B to its target? why?
package it in a lipid associated delivery system
decrease toxicity
What is important about giving amphotericin B orally?
it is poorly absorbed from the GI tract
only good for treating fungi in lumen of GI tract and cannot be treated for a systemic disease
Amphotericin B is given through IV for systemic fungal infections. describe its D, M, E and its t1/2
distribution: binds to 90% of serum proteins and widely distributed in most tissues
metabolized mostly
excreted slowly in the urine over many days
t 1/2=> 15 days
Are there any contraindications that would limit dosage?
most impairments have little impact on drug concentrations so no dose adjustment required
Does amphotercin B reach CNS? does this alter administration for meningitis?
2-3% of blood level is reached in CNS
occasionaly intrathecal therapy for certain types of fungal meningitis is necessary
