Protein synthesis inhibitors w/ distinct actions

Question 1

What are the protein synthesis inhibitors with distinct mechanisms of action?

Answer 1

• Retapamulin
• Mupirocin
• Linezolid
• streptogramins

Question 2

What is the mechanism of action for retapamulin?

Answer 2

inhibit protein synthesis in bacteria by interfering with peptidyl transferase

1. preventing formation of active 50S ribosomal subunit
2. inhibit peptidyl transferase
3. blocks P-site interactions

Question 3

How is retapamulin administered? and what is its structure?

Answer 3

topical ointment

considered to be a pleuromutilin antibiotic

Question 4

How is mupirocin administered?

Answer 4

topical cream and ointment

Question 5

What is the mechanism of action for mupirocin?

Answer 5

inhibits the tRNA that transports isoleucine

results in NO cross-resistance with any other antimicrobials

Question 6

What is the mechanism of action for linezolid?

Answer 6

interferes with protein synthesis by binding to a unique RNA site on 50S subunit

prevents formation of functional 70S complex

Question 7

What are the drugs of Streptogramins?

Answer 7

combination of quinupristin and dalfopristin

Question 8

Where does the combo of quinupristin/dalfopristin act?

Answer 8

act at bacterial ribosomes and interferes with protein synthesis

Question 9

What is the mechanism of action for quinupristin?

Answer 9

irreversibly blocks ribosomes and inhibits late phases of protein synthesis

Question 10

What is the mechanism of action for dalfopristin?

Answer 10

inhibits early phases of protein synthesis

Question 11

What is the combination of quinupristin and dalfopristin used to treat?

Answer 11

life-threatening infections caused by vancomycin resistant enterococci and complicated skin infections caused by MRSA