SimUtext Flashcards
a unit of heredity information that codes for a product such as a protein
gene
alternate versions of a gene
alleles
- such as humans
- two copies of each gene inheriting one from each parent
diploid organisms
an organisms whose two copies are the same allele is what for that gene
homozygous
an individual with two different alleles
heterozygous
certain genotypes are associated with higher or lower what, depending on the local environment of the individual organism
fitness
refers to how successfully an individual passes their genes to future generations
fitness
What occurs when the heterozygous genotype for a particular gene confers higher fitness than do homozygous genotypes
heterozygote advantage
What three conditions must be met for evolution by natural selection to occur?
- there must be variation within the population
- the mechanism that creates the variation within the population
- the variation must lead to differences in fitness
an inherited disease in which people produce malformed red blood cells that are sickle-shaped instead of disc-shaped, despite high mortality this persists in some areas
sickle-cell disease
a deadly mosquito-borne disease in which humans red blood cells are invaded by a protozoan parasite
malaria
sickle-cell disease occurs when a person is homozygous for the sickle-cell allele (HbS) of what gene
hemoglobin
Individuals with what genotype have increased fitness in environments where malaria is common
HbA/HbS
New alleles are created through what
random mutations of DNA
the persistence of a new allele in a population depends in part on the degree to which the allele confers a what which may depend on the local environment
fitness advantage
a mechanism of evolution in which random events affect the frequency of alleles in a population
genetic drift
What two mechanism are not mutually exclusive
genetic drift and natural selection
when the relative fitness of a particular genotype is high what may have a larger effect on allele frequency than what
- natural selection
- genetic drift
Genetic drift follows the rules of what and thus the size of a population influences the effect that genetic drift can have
- in small populations a particulars alleles frequency is more likely to become fixed and either disappear entirely or become the only allele circulating in the population
- in large populations allele frequency tend to remain relatively stable over time
probability
a population in what is not evolving meaning its allele frequencies are remaining constant
Hardy-Weinberg equilibrium
For HWE to occur what conditions must be met?
- no natural selection, all genotypes are equally adaptive
- no genetic drift, randomness is not a factor
- mutation
- no migration
- random mating, offspring genotypes are random combinations of parental alleles
used to predict allele and genotype frequencies for a gene with two alleles in a population in this
HWE
What symbols represent the frequency of the two different alleles
p and q
What is the HWE equation
p^2 + 2pq + q^2 = 1
the frequency of individuals that are homozygous for the first allele
p^2
the frequency of heterozygous individuals
2pq
the frequency of individuals that are heterozygous for the other allele
q^2
HWE is a what that describes expected genotype frequencies in a population that is not undergoing evolution
- simplified systems describing expectations without influencing factors
- useful because they allow you to generate and test alternative hypotheses which posit that something interesting such as evolution is happening
Null Model
How can scientist test if evolution is occurring in a particular gene
they can measure the genotype frequencies in a population and compare the frequencies to those predicted by the HWE
if the difference between observed and expected frequencies is statistically significant the null hypothesis can be what which is used as evidence that the population is evolving
rejected
Use of simulated populations and the HW null model suggest that if malaria were to be eradicated the what associated with the sickle cell allele HbS would disappear and there would be strong selection against HbS unless sickle-cell disease were also effectively eradicated
heterozygote advantage
a change in the genetic composition of a population from one generation to the next
evolution
What two things are intertwined
evolution and ecology
Evolution is often facilitated by what and the resulting impacts can be ecologically important
ecological processes
What are the four mechanisms of evolution
- mutation
- natural selection
- migration
- genetic drift
What mechanisms are not exclusive of each other and often act simultaneously
evolution mechanisms
evolution by what happens when individuals with certain traits survive and reproduce at higher rates than others
natural selection
numerous examples from laboratories and natural populations demonstrate that substantial evolution in ecologically relevant traits does what
can happen rapidly, sometimes in just a few generations
traits associated with what become common
survival and reproduction
traits associated with what become rare
early death and reproductive failure
What theory applies to any population in which the requirements are met
natural selection
The theory of evolution can be framed in the language of what
modern genetics
evolution can be defined as change in what across generations or among populations
allele frequencies
When there are differences in phenotype that are at least partly due to differences in genotype and some phenotypes have higher what than others, then allele frequencies automatically change
fitness
Alleles associated with what become common
high fitness
Alleles associated with what disappear
low fitness
Allele frequencies may also change across generations due to what which is evolution by genetic drift
purely random events that result in sampling error
a form of genetic drift that occurs when a few individuals from a source population establish a new population, usually the allele frequencies will be different in the new population than they are in the source population
Founder effect
What also occurs when individuals migrate from one population to another, if the migration alters allele frequencies in one or the other population
evolution
What can create new alleles in a population which changes allele frequencies across generation which leads to evolution
genetic mutation
What do not act exclusively of each other
the four mechanisms of evolution
In what evolution can occur via any combination of mechanisms acting simultaneously
natural populations
Understanding the mechanism of what helps researchers and farmers devise ways to control crop pests like the pink bollworm without encouraging rapid evolution of resistance
decent with modification
What populations evolve resistance to Bt toxins because normally rare resistant genotypes enjoy much higher fitness than susceptible genotypes on Bollgard cotton
Pink Bollworm
What uses fields planted with patches of Bollgard and patches of normal cotton
The high-dose/refuge strategy
What is well protected against bollworms
Bollgard cotton
The normal cotton allows susceptible bollworms to survive reducing what
the fitness advantage associated with resistance
The evolution of antibiotic resistance in populations of disease causing bacteria is what
a major health concern
What is ongoing but is unlikely to be a long term solution to the problem
The development of novel antibiotics
Other strategies are needed to help reduce the evolution of resistance in what
pathogenic bacteria
When resources are limited individuals must do what
compete
the complete set of conditions under which an organism could potentially survive and reproduce
fundamental niche
the subset of the fundamental niche describing the conditions under which an organism actually lives given limitations created by interactions with other species
realized niche