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GI Fitzy > Simple List of drugs for Diarrhea/Constipation > Flashcards

Simple List of drugs for Diarrhea/Constipation Flashcards

1
Q

Cisapride

A

5HT4 agonist and weak 5H3 antagonist (prokinetic)

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2
Q

Macrolide (erythromycin)

A

activate motillin receptors

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3
Q

Metaclopramide

A

D2 antagonist and inhibits the D2 inhibition of ACh contraction. Crosses BBB so also antiemetic

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4
Q

Domperidone

A

D2 antagonist that inhibits the D2 inhibition of ACh contraction. doesn’t cross BBB

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5
Q

Diphenoxylate

A

Opiate with some euphoric side effects

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6
Q

Loperamide

A

Opiate with no CNS effects

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7
Q

Cholestyramine

A

Bile acid binding resin

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8
Q

Colestipol

A

Bile acid binding resin

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9
Q

Kaolin

A

Absorbant

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10
Q

Pectin

A

Absorbant (undigestible sugar notice the name is like amylopectin)

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11
Q

Bismuth subsalicylate

A

Salicylate inhibits PG and Cl secretion in INTESTINE (note bismuth basically does opposite in stomach)

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12
Q

Octreotide

A

Somatostatin analogue

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13
Q

Docusate

A

Stool softener: mix with aqueous and fatty substance to make softer stool

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14
Q

Mineral oil:

A

stool softener and lubricates feces so less water absorption

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15
Q

Dietary Fiber, Methylcellulose, Psyllium

A

Bulk laxatives

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16
Q

Anthraquinone Derivatives

A

Contact Cathartic. Uknown mechanism but more peristalsis in colon (includes senna)

17
Q

Bisacodyl

A

Contact Cathartic that is prodrug with 6 hour latency and peristalsis in colon. Not used often b/c cardiac toxicity

18
Q

Castor oil

A

EXTREMELY POTENT contact cathartic and works in small intestinee and large intestinee after it is hydrolyzed in intestine to ricnoleic acide

19
Q

Lactulose

A

Osmotic cathartic: nonabsorbed sugar broken by bacteria and makes farting

20
Q

Magnesium Hydroxide

A

Osmotic cathartic. Can be hyper magnesium in body if renal insufficiency and dEATH

21
Q

Sodium Phopshate

A

Osmotic cathartic

22
Q

Polythelen Glycol

A

DUH osmotic cathartic

23
Q

Lubiprostone

A

Increase Chloride Channel secretion: Cathartic. FETAL LOSS

24
Q

Alvimopan

A

Opioid receptor antagonist used in postop ileus

25
Q

Methylnaltrexone

A

Opioid reepotr antagonist in advanced illness

26
Q

Amytryptaline

A

TCA which has side effect of constipation, so used in diarrheal IBS

27
Q

Desipramine

A

TCA which has side effect of constipation so used in diarrheal IBS

28
Q

Paroxetine

A

SSRI: side effect of diarrhea so helps with constipation IBS

29
Q

Fluoxetine

A

SSRI: side effect of diarrhea so helps with constipation IBS

30
Q

Sertraline

A

SSRI: side effect of diarrhea so helps with constipation IBS

31
Q

Alosetron

A

5HT3 antagonist: anti diarrheal used for IBS

32
Q

Tegaserod

A

5HT4 agonist for constipation IBS, but not used b/c arrhythmia

GI Fitzy (6 decks)

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