Signalling Transduction Flashcards
What is c-kit?
A growth factor receptors
What primarily mediate signalling pathways? And why is it important(implication in cancer)?
Growth factors, it’s important because they downregulate the many important cellular processes such as differentiation, apoptosis, proliferation. If abnormally expressed can play a role in tumour initiation, progression and response to treatment
What are other parts of signalling pathways other than growth factors that can be mutated and is associated with cancer?
Growth factor receptors
What regulates transcription factor activity in the nucleus?
Signalling pathways
What amino acids are phosphates added to?
Serine, threonine, tyrosine
What is signal particle dependent on?
Receptor type and cell types
What do adaptor proteins do?
They are scaffolds for signalling networks
Outline the signalling pathway of PLC pathway. What is PKC?
Plc activated to cleave pip2 IP3 and DAG they release calcium from ER together they activate the PKC.
It’s a serine threonine kinase
What does activated PKC do?
Involved in mitogenic signalling can transcribe c-much, regulate cystolic ph, change potassium concentration
What other molecules does PKC activate?
P120ras GAP
AKT
There is a positive feedback where insulin or egfr is always turned on when there is too much PKC
False, a negative feedback
Other pathways other PI3K can activate PKC
True
What is The function of AKT cellularly? And what does it act on? What regulates it?
Survival(phosphorylation of (BAD), proliferation(negatively regulates p21 and p27), regulating cell growth(activates mTOR)
PTEN phosphorylates AKT And regulates it
What is mTOR’s function? What drug inhibits it?
Cell growth overall but does have a role in protein synthesis, autophagy, transcription, proliferation. Rapamycin
