Signalling mechanisms in growth and division Flashcards
1
Q
Key components of signalling pathways
A
- regulation of enzyme activity by protein phosphorylation (kinases)
- adapter proteins
- regulation of GTP-binding proteins
2
Q
Growth factor stimulation of signalling pathways
A
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3
Q
G0 phase
A
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4
Q
Key role of c-Myc
A
-oncogene which is overexpressed in many tumours
5
Q
Signalling by peptide growth factors
A
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6
Q
Adaptor proteins
A
- Tyrosine phosphorylation provides docking sites for adaptor proteins
- Protein-protein interactions: protein binding bringing proteins together
7
Q
GTP binding (G) proteins
A
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8
Q
RPTKs signal to Ras
A
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9
Q
The ERK cascade
A
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10
Q
Cyclins
A
- transiently expressed at specific points in the cell cycle
- regulated at expression level
- synthesised then degraded
11
Q
Role of activated Cdks
A
-phosphorylate proteins (on serine or threonine) to drive cell cycle progression
12
Q
Cdk regulation by phosphorylation
A
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13
Q
Regulated expression of Cyclins/Cdks
A
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14
Q
Regulation of gene expression by Rb
A
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15
Q
Cdk inhibitors (CKIs)
A
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