Signal Transduction

Question 1

What is tetrodotoxin?

Answer 1

blocks Na+ channels in nerves, fugu in fish, cause anesthetic effect

Question 2

What is Mg2+, Ca2+?

Answer 2

competitive inhibitor of Ca2+ channels,

Question 3

What is botulinum toxin?

Answer 3

cuts the 25 kD part of SNAP (Ca2+ sensing region) of the SNARE, preventing vesicle release of Each with Ca2+ increase

Question 4

What is rocuronium (curium)?

Answer 4

non depolarizing blocker of ACh at nicotinic receptors of skeletal muscle

Question 5

What is succinylcholine

Answer 5

depolarizing blocker of ACh (first stimulates before blocking) at nicotinic receptors of skeletal muscle

Question 6

What is neostigime?

Answer 6

reversible inhibition of AChE to treat diseases like myasthenia gravis

Question 7

What is atropine?

Answer 7

blocks musarinic receptors (parasympathetic) of the heart, increasing heart beat

Question 8

What are drugs with -tropium?

Answer 8

inhibits muscarinic receptors of airways, relaxing the airways

Question 9

What is phenylepiphrene?

Answer 9

activates a1, constricting smooth muscle and blood vessels

Question 10

What are drugs that end in -opronol?

Answer 10

inhibit B1 (sympathetic) innervation of the heart, decreasing heart beat

Question 11

What are drugs that end in -terol?

Answer 11

activates B2 (sympathetic) receptor, relaxes airways

Question 12

What receptor increases heart beat?

Answer 12

B1 (sympathetic), signaled by NE/E

Question 13

What receptor decreases heart beat?

Answer 13

muscarinic (parasympathetic), signaled by ACh

Question 14

What receptor constricts blood vessels?

Answer 14

a1 (sympathetic)

Question 15

What receptor relaxes blood vessels?

Answer 15

B2 (sympathetic), signaled by E mostly

Question 16

What receptors constricts airways?

Answer 16

muscarinic (parasympathetic), signaled by ACh

Question 17

What receptors relax airways?

Answer 17

B2 (sympathetic), signaled by both E/NE