Clinical Medicine Flashcards
What is association?
rceived relationship between two variables, but does not necessarily indicate a causal relationship due to the presence of possible confounding variables, chance, or false associations
What are the criteria for causation?
Demonstrated association
Temporality - cause precedes effect
Altering the cause alters the probability of the effect
What can both case-control and cohort studies do?
Both studies are able to determine associations between an exposure and an outcome when a randomized controlled trial is not feasible
What is a cohort study?
A study population is defined by whether or not they have had an exposure (exposure-based) and then followed for a period of time to determine whether or not they develop an outcome - must be free of outcome at the start of the study
What is a case control study?
Study population is defined by whether or not they have an outcome (outcome-based with selected controls) and then look back to see whether or not they had an exposure - ALWAYS retrospective
What are strengths of a cohort study?
Best available when RCT isn’t possible, can look at multiple outcomes for a single exposure, exposure status is measured before outcome, can study many risk factors, can establish disease incidence
What are weaknesses of cohort study?
Often require large populations, difficult with rare events, can be limited to pre-collected data, expensive, potential for bias (recall, measurement, loss to follow up)
What are strengths of case control studies?
Efficient for studying rare outcomes and long latency, can look at multiple exposures, less time consuming/expensive, easy to set up and execute quickly
What are weakness of case control studies?
Susceptible to bias given retrospective nature, cannot give information on prevalence/incidence, not good for rare exposures, frequently executed poorly, more sensitive to risk of misclassification/confounding
What is the relative risk ratio?
a/(a+b)/c/(c+d)
What is the odds ratio?
ad/bc
When can the odds ratio approximate the RR?
when incidence is low
What is attributable risk?
a/(a+b) - c/(c+d)
What is the NNH (number needed to harm)?
1/AR
What is sampling bias?
bias in which a sample is collected in such a way that some members of the intended population have a lower sampling probability than others
What is selection bias?
bias introduced by the selection of individuals, groups or data for analysis in such a way that proper randomization is not achieved, thereby ensuring that the sample obtained is not representative of the population intended to be analyzed
What is a confounder?
variable that influences both the dependent variable and independent variable, causing a spurious association (causal concept)
What is recall bias?
atic error that occurs when participants do not remember previous events or experiences accurately or omit details: the accuracy and volume of memories may be influenced by subsequent events and experiences
What is measurement bias?
systematically overstates or understates the true value of the measurement
What is surveillance bias?
arises when patients in one exposure group have a higher probability of having the study outcome detected, due to increased surveillance, screening or testing of the outcome itself, or associated symptoms
What is spectrum bias?
each arm (cases and controls) had to have an equal opportunity to have the exposure (spectrum of possible exposure)
What is planned care?
pre visit chart review
for each problem listed, consider SOAP
What is discovery phase?
Genome-wide association studies (GWAS) to discover SNPs and potentially pathogenic variants that affect therapeutic drug response
What is clinical testing based on variant type?
Individual-specific genetic testing assays (e.g. del/dup, NGS, single allele assays, etc.) that test for variants of phenotypic importance that affect therapeutic drug response