Clinical Medicine Flashcards

1
Q

What is association?

A

rceived relationship between two variables, but does not necessarily indicate a causal relationship due to the presence of possible confounding variables, chance, or false associations

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2
Q

What are the criteria for causation?

A

Demonstrated association
Temporality - cause precedes effect
Altering the cause alters the probability of the effect

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3
Q

What can both case-control and cohort studies do?

A

Both studies are able to determine associations between an exposure and an outcome when a randomized controlled trial is not feasible

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4
Q

What is a cohort study?

A

A study population is defined by whether or not they have had an exposure (exposure-based) and then followed for a period of time to determine whether or not they develop an outcome - must be free of outcome at the start of the study

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5
Q

What is a case control study?

A

Study population is defined by whether or not they have an outcome (outcome-based with selected controls) and then look back to see whether or not they had an exposure - ALWAYS retrospective

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6
Q

What are strengths of a cohort study?

A

Best available when RCT isn’t possible, can look at multiple outcomes for a single exposure, exposure status is measured before outcome, can study many risk factors, can establish disease incidence

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7
Q

What are weaknesses of cohort study?

A

Often require large populations, difficult with rare events, can be limited to pre-collected data, expensive, potential for bias (recall, measurement, loss to follow up)

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8
Q

What are strengths of case control studies?

A

Efficient for studying rare outcomes and long latency, can look at multiple exposures, less time consuming/expensive, easy to set up and execute quickly

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9
Q

What are weakness of case control studies?

A

Susceptible to bias given retrospective nature, cannot give information on prevalence/incidence, not good for rare exposures, frequently executed poorly, more sensitive to risk of misclassification/confounding

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10
Q

What is the relative risk ratio?

A

a/(a+b)/c/(c+d)

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11
Q

What is the odds ratio?

A

ad/bc

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12
Q

When can the odds ratio approximate the RR?

A

when incidence is low

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13
Q

What is attributable risk?

A

a/(a+b) - c/(c+d)

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14
Q

What is the NNH (number needed to harm)?

A

1/AR

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15
Q

What is sampling bias?

A

bias in which a sample is collected in such a way that some members of the intended population have a lower sampling probability than others

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16
Q

What is selection bias?

A

bias introduced by the selection of individuals, groups or data for analysis in such a way that proper randomization is not achieved, thereby ensuring that the sample obtained is not representative of the population intended to be analyzed

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17
Q

What is a confounder?

A

variable that influences both the dependent variable and independent variable, causing a spurious association (causal concept)

18
Q

What is recall bias?

A

atic error that occurs when participants do not remember previous events or experiences accurately or omit details: the accuracy and volume of memories may be influenced by subsequent events and experiences

19
Q

What is measurement bias?

A

systematically overstates or understates the true value of the measurement

20
Q

What is surveillance bias?

A

arises when patients in one exposure group have a higher probability of having the study outcome detected, due to increased surveillance, screening or testing of the outcome itself, or associated symptoms

21
Q

What is spectrum bias?

A

each arm (cases and controls) had to have an equal opportunity to have the exposure (spectrum of possible exposure)

22
Q

What is planned care?

A

pre visit chart review

for each problem listed, consider SOAP

23
Q

What is discovery phase?

A

Genome-wide association studies (GWAS) to discover SNPs and potentially pathogenic variants that affect therapeutic drug response

24
Q

What is clinical testing based on variant type?

A

Individual-specific genetic testing assays (e.g. del/dup, NGS, single allele assays, etc.) that test for variants of phenotypic importance that affect therapeutic drug response

25
What is a disadvantage of assays?
assays will not cover all genotypic outcomes (e.g. if patient has a rare variant that affects metabolism, then it might not get caught)
26
Why are translation tables important?
Diplotype tables (a.k.a translation tables) detail the potential outcomes for combinations of diplotype: will tell you dosing information based on alleletypes of patient
27
What is the goal of TDM (therapeutic drug monitoring)?
To optimize the drug dose so that the patient’s drug concentrations remain within the therapeutic range; generally performed when drug reaches steady-state
28
What are four attributes of drugs that make them amenable to therapeutic monitoring?
Known relationship between dose & blood/serum/plasma concentrations Narrow therapeutic window High patient variability in pharmacokinetics Severe adverse effects
29
What is the innovative Medicare model?
adds outside-the-visit chronic care management (often done by non-physician team members).
30
What is the traditional Medicare model?
Medicare reimbursed with the focus on acute, episodic care
31
What are the basic principles of the chronic care model?
lower cost, better care and better health | health care and community provide interactions between informed/activated patient and prepared proactive practice team
32
List the components of the Patient-Centered Medical Home?
Personal Physician - each patient has an ongoing relationship with a personal physician trained for first contact and continuous care. Physician-directed medical practice - personal physician leads a team of individuals at the practice level who take responsibility for the ongoing care of patients Payment and Med Economics: payment appropriately recognizes the added value provided to patients who have a PCMH and work that’s done outside of face-to-face. Quality and Safety - advocacy for attainment of optimal, patient centered outcomes defined by a collab care planning process. EBM and CD support tools guide decision making - QI is key here. Whole person orientation - physician responsible for the patient’s: health care needs, learning of self-management principles, and arranging f/u care Enhanced access to care -- access is available through systems such as open-access scheduling, extended hours, and new options for communications between patients and staff. Care coordination and integration - care coordinated across all elements of the health system facilitated by tech to assure they get the care when they need it. (PPP-QWEC)
33
What is the Ask-Tell-Ask method of motivational interviewing?
Ask: assess the pt’s baseline knowledge Tell: use simple, clear, concise language; avoid medical jargon; speak slowly; “chunk” info by pausing after a concept; limit 1-3 key messages and emphasize these messages; use visual aids and written instructions to reinforce key messages. Ask: request teach-back (ask the pt to repeat the instructions they have just been given); expect questions: “What questions do you have?” instead of “Do you have any questions?”
34
Why do we share information in MI?
``` Optimize outcomes (better outcomes if patients know what’s going on/why the plan is the way it is) Promote pt autonomy by allowing patients to share in decision-making Promote pt self-efficacy ```
35
What is shared decision making?
A strategy of partnership between doctor and pt that helps pts make “an evidence-based treatment choice”
36
When is shared decision making applicable?
appropriate for preference-sensitive conditions in which there is more than one choice of therapy, including the choice of no intervention
37
What encounters in which MI would be beneficial?
adherence to medication, smoking cessation, diet and exercise, risky sexual behavior, alcohol use disorder, blood pressure
38
What are the techniques of MI?
``` OARS: Open ended questions Affirmative statements Reflections Summary statements ```
39
What is the Righting Reflex?
When the physician tells the patient how to fix a behavioral problem
40
What is Roll with Resistance?
It is best to sidestep any resistance and to avoid trying to fix and solve every problem
41
What is the Develop Discrepancy?
Highlight areas of inconsistency between behavior and goals or values
42
What is Decisional Balance?
Think about costs and benefits of changing behavior vs. not changing behavior